Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565305513> ?p ?o ?g. }
- W2565305513 abstract "The idea of using antibodies to restrain HIV viral replication has been a growing interest since many years ago. HIV-patient serum with elite virus-neutralizing breadth has led to preparation of broadly neutralizing antibodies (BrNAbs) with long and highly mutated CDRH3 domains that can neutralize a broad array of viral strains and prevent transmission in animal models. Recent advances have resulted in the discovery of BrNAbs that are more potent and can neutralize many HIV-1 subtypes. However, elicitation of these antibodies in infected individuals usually requires a long time of antigen exposure. Though, BrNAbs are shown to be successful either therapeutically or prophylactically against HIV-1, production of these antibodies in bulk, commercial-sized batches is expensive and non-affordable particularly for poor countries. Therefore, more durable preventative or therapeutic strategies are required. Immunization of the cows with HIV Env is shown to be capable of producing 20 kg purified anti-HIV-1 BrNAbs and this amount could be sufficient for 2 million × 10 mg doses for formulation and pre-clinical testing as an HIV microbicide. In addition, bovine immunoglobulins typically have variable third heavy complementarity determining regions (CDRH3) that may potentially facilitate access to antigenic epitopes that are very difficult for other species to engage. Thus, cows could be engaged to elicit anti-HIV antibodies with the features of human BrNAbs and bovine colostrum could be a promising and cheap resource for development of combination microbicides." @default.
- W2565305513 created "2017-01-06" @default.
- W2565305513 creator A5029935701 @default.
- W2565305513 creator A5049119347 @default.
- W2565305513 creator A5073880534 @default.
- W2565305513 date "2016-01-01" @default.
- W2565305513 modified "2023-10-02" @default.
- W2565305513 title "Broad Neutralizing Antibodies to HIV Env and Other Complex Viral Antigens from Vaccinated Cows" @default.
- W2565305513 cites W114558098 @default.
- W2565305513 cites W1571661492 @default.
- W2565305513 cites W1603383430 @default.
- W2565305513 cites W1966455988 @default.
- W2565305513 cites W1969689981 @default.
- W2565305513 cites W1972909284 @default.
- W2565305513 cites W1974431423 @default.
- W2565305513 cites W1976897618 @default.
- W2565305513 cites W1978398372 @default.
- W2565305513 cites W1979058462 @default.
- W2565305513 cites W1979882766 @default.
- W2565305513 cites W1981981290 @default.
- W2565305513 cites W1989053318 @default.
- W2565305513 cites W1989268923 @default.
- W2565305513 cites W1990981444 @default.
- W2565305513 cites W1991125965 @default.
- W2565305513 cites W1995466180 @default.
- W2565305513 cites W2001927093 @default.
- W2565305513 cites W2001959906 @default.
- W2565305513 cites W2001966687 @default.
- W2565305513 cites W2007454130 @default.
- W2565305513 cites W2008547312 @default.
- W2565305513 cites W2009151161 @default.
- W2565305513 cites W2010996470 @default.
- W2565305513 cites W2012362118 @default.
- W2565305513 cites W2014764918 @default.
- W2565305513 cites W2018123062 @default.
- W2565305513 cites W2020596573 @default.
- W2565305513 cites W2022585618 @default.
- W2565305513 cites W2025181104 @default.
- W2565305513 cites W2028450449 @default.
- W2565305513 cites W2029135056 @default.
- W2565305513 cites W2034148546 @default.
- W2565305513 cites W2037302035 @default.
- W2565305513 cites W2044369525 @default.
- W2565305513 cites W2045134344 @default.
- W2565305513 cites W2049514370 @default.
- W2565305513 cites W2052150715 @default.
- W2565305513 cites W2054989706 @default.
- W2565305513 cites W2055253070 @default.
- W2565305513 cites W2055378587 @default.
- W2565305513 cites W2058776846 @default.
- W2565305513 cites W2060119188 @default.
- W2565305513 cites W2061410538 @default.
- W2565305513 cites W2063219607 @default.
- W2565305513 cites W2068519589 @default.
- W2565305513 cites W2072149435 @default.
- W2565305513 cites W2074401584 @default.
- W2565305513 cites W2074867344 @default.
- W2565305513 cites W2077219861 @default.
- W2565305513 cites W2078095517 @default.
- W2565305513 cites W2078913377 @default.
- W2565305513 cites W2080089116 @default.
- W2565305513 cites W2083726777 @default.
- W2565305513 cites W2084310667 @default.
- W2565305513 cites W2085234074 @default.
- W2565305513 cites W2090438768 @default.
- W2565305513 cites W2090763940 @default.
- W2565305513 cites W2093209837 @default.
- W2565305513 cites W2095553811 @default.
- W2565305513 cites W2096387523 @default.
- W2565305513 cites W2100021845 @default.
- W2565305513 cites W2101429257 @default.
- W2565305513 cites W2101835696 @default.
- W2565305513 cites W2103425962 @default.
- W2565305513 cites W2106358727 @default.
- W2565305513 cites W2108927023 @default.
- W2565305513 cites W2118274231 @default.
- W2565305513 cites W2118820599 @default.
- W2565305513 cites W2119711460 @default.
- W2565305513 cites W2120156385 @default.
- W2565305513 cites W2122617162 @default.
- W2565305513 cites W2122962689 @default.
- W2565305513 cites W2124359177 @default.
- W2565305513 cites W2129080603 @default.
- W2565305513 cites W2129973151 @default.
- W2565305513 cites W2135151522 @default.
- W2565305513 cites W2135792930 @default.
- W2565305513 cites W2135847964 @default.
- W2565305513 cites W2139440963 @default.
- W2565305513 cites W2139842359 @default.
- W2565305513 cites W2140070226 @default.
- W2565305513 cites W2142642621 @default.
- W2565305513 cites W2144234477 @default.
- W2565305513 cites W2147925479 @default.
- W2565305513 cites W2154395248 @default.
- W2565305513 cites W2157820405 @default.
- W2565305513 cites W2159368585 @default.
- W2565305513 cites W2162546635 @default.
- W2565305513 cites W2166216392 @default.
- W2565305513 cites W2166378435 @default.
- W2565305513 cites W2166859411 @default.