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• W2565348045 abstract "Circulating tumor cells (CTC) have become an important biomarker in patients with advanced prostate cancer. CTC count has been demonstrated to be a prognostic factor for overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC). In localized prostate cancer, a clear correlation between CTC counts and clinicopathological risk parameters and outcome has not been observed. Currently, the focus of research is shifting from CTC enumeration towards molecular characterization of CTC leading to the discovery of markers predicting treatment response. The role of androgen receptor splice variants expressed by CTC as markers of resistance to abiraterone and enzalutamide has been assessed by various studies. The identification of CTC markers predicting treatment response represents a key step to guide the selection of treatment (e.g., abiraterone/enzalutamide vs taxanes), particularly in patients with mCRPC. As an alternative to CTC, the analysis of circulating tumor DNA has been shown to enable a noninvasive disease characterization having high potential to promote precision oncology." @default.
• W2565348045 created "2017-01-06" @default.
• W2565348045 creator A5042022681 @default.
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• W2565348045 creator A5072818969 @default.
• W2565348045 creator A5086583298 @default.
• W2565348045 date "2019-01-01" @default.
• W2565348045 modified "2023-10-16" @default.
• W2565348045 title "Circulating tumor cells and their role in prostate cancer" @default.
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• W2565348045 doi "https://doi.org/10.4103/aja.aja_29_17" @default.
• W2565348045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6337952" @default.
• W2565348045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28836508" @default.
• W2565348045 hasPublicationYear "2019" @default.
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