FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565370918> ?p ?o ?g. }

• W2565370918 endingPage "390" @default.
• W2565370918 startingPage "386" @default.
• W2565370918 abstract "Introduction: Despite adjuvant systemic therapy in patients with completely resected non-small-cell lung cancer (NSCLC), many will subsequently relapse. We investigated treatment choices at relapse and assessed the effect of palliative platinum doublet systemic therapy in this population. Methods: With research ethics board approval, we performed a retrospective chart review of all patients with resected NSCLC who received adjuvant systemic therapy from January 2002 until December 2008 at our institution. The primary outcome was the response rate to first-line palliative systemic therapy among patients who relapsed. Results: We identified 176 patients who received adjuvant platinum doublet systemic therapy (82% received cisplatin–vinorelbine). In the 85 patients who relapsed (48%), median time to relapse was 18.5 months (95% confidence interval: 15 months to 21.3 months). Palliative systemic therapy was given in 43 patients. Of those 43 patients, 25 (58%) were re-challenged with platinum doublet systemic therapy, with a response rate of 29% compared with 18% in 18 patients who received other systemic therapy (p = 0.48). We observed a trend toward an increased clinical benefit rate (complete response + partial response + stable disease) in patients who were treated with a platinum doublet (67% vs. 41%, p = 0.12). Median overall survival (OS) from relapse was 15.3 months in patients receiving palliative systemic therapy and 7.8 months in those receiving best supportive care alone. Compared with patients treated with non-platinum regimens, the platinum-treated group experienced longer survival after relapse (18.4 months vs. 9.7 months, p = 0.041). Conclusions: In patients previously treated with adjuvant systemic therapy, re-treatment with platinum doublet chemotherapy upon relapse is feasible. Moreover, compared with patients receiving other first-line systemic therapy, patients receiving platinum doublets experienced higher response rates and significantly longer survival." @default.
• W2565370918 created "2017-01-06" @default.
• W2565370918 creator A5009677422 @default.
• W2565370918 creator A5013083743 @default.
• W2565370918 creator A5052379271 @default.
• W2565370918 creator A5086914791 @default.
• W2565370918 date "2016-12-01" @default.
• W2565370918 modified "2023-10-16" @default.
• W2565370918 title "Chemotherapy in Recurrent Advanced Non-Small-Cell Lung Cancer After Adjuvant Chemotherapy" @default.
• W2565370918 cites W1935885922 @default.
• W2565370918 cites W1975536376 @default.
• W2565370918 cites W2028776745 @default.
• W2565370918 cites W2037139573 @default.
• W2565370918 cites W2042174395 @default.
• W2565370918 cites W2054841768 @default.
• W2565370918 cites W2082732863 @default.
• W2565370918 cites W2104504726 @default.
• W2565370918 cites W2106787323 @default.
• W2565370918 cites W2117994949 @default.
• W2565370918 cites W2127342594 @default.
• W2565370918 cites W2151518427 @default.
• W2565370918 cites W2158234609 @default.
• W2565370918 cites W2168150041 @default.
• W2565370918 cites W2169999184 @default.
• W2565370918 cites W4297939389 @default.
• W2565370918 cites W76785663 @default.
• W2565370918 doi "https://doi.org/10.3747/co.23.3191" @default.
• W2565370918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5176371" @default.
• W2565370918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28050134" @default.
• W2565370918 hasPublicationYear "2016" @default.
• W2565370918 type Work @default.
• W2565370918 sameAs 2565370918 @default.
• W2565370918 citedByCount "22" @default.
• W2565370918 countsByYear W25653709182017 @default.
• W2565370918 countsByYear W25653709182018 @default.
• W2565370918 countsByYear W25653709182019 @default.
• W2565370918 countsByYear W25653709182020 @default.
• W2565370918 countsByYear W25653709182021 @default.
• W2565370918 countsByYear W25653709182022 @default.
• W2565370918 countsByYear W25653709182023 @default.
• W2565370918 crossrefType "journal-article" @default.
• W2565370918 hasAuthorship W2565370918A5009677422 @default.
• W2565370918 hasAuthorship W2565370918A5013083743 @default.
• W2565370918 hasAuthorship W2565370918A5052379271 @default.
• W2565370918 hasAuthorship W2565370918A5086914791 @default.
• W2565370918 hasBestOaLocation W25653709181 @default.
• W2565370918 hasConcept C121608353 @default.
• W2565370918 hasConcept C126322002 @default.
• W2565370918 hasConcept C141071460 @default.
• W2565370918 hasConcept C143998085 @default.
• W2565370918 hasConcept C159110408 @default.
• W2565370918 hasConcept C185926286 @default.
• W2565370918 hasConcept C2776256026 @default.
• W2565370918 hasConcept C2776694085 @default.
• W2565370918 hasConcept C2777982462 @default.
• W2565370918 hasConcept C2778239845 @default.
• W2565370918 hasConcept C2780350996 @default.
• W2565370918 hasConcept C2908647359 @default.
• W2565370918 hasConcept C2994186709 @default.
• W2565370918 hasConcept C530470458 @default.
• W2565370918 hasConcept C71924100 @default.
• W2565370918 hasConcept C99454951 @default.
• W2565370918 hasConceptScore W2565370918C121608353 @default.
• W2565370918 hasConceptScore W2565370918C126322002 @default.
• W2565370918 hasConceptScore W2565370918C141071460 @default.
• W2565370918 hasConceptScore W2565370918C143998085 @default.
• W2565370918 hasConceptScore W2565370918C159110408 @default.
• W2565370918 hasConceptScore W2565370918C185926286 @default.
• W2565370918 hasConceptScore W2565370918C2776256026 @default.
• W2565370918 hasConceptScore W2565370918C2776694085 @default.
• W2565370918 hasConceptScore W2565370918C2777982462 @default.
• W2565370918 hasConceptScore W2565370918C2778239845 @default.
• W2565370918 hasConceptScore W2565370918C2780350996 @default.
• W2565370918 hasConceptScore W2565370918C2908647359 @default.
• W2565370918 hasConceptScore W2565370918C2994186709 @default.
• W2565370918 hasConceptScore W2565370918C530470458 @default.
• W2565370918 hasConceptScore W2565370918C71924100 @default.
• W2565370918 hasConceptScore W2565370918C99454951 @default.
• W2565370918 hasIssue "6" @default.
• W2565370918 hasLocation W25653709181 @default.
• W2565370918 hasLocation W25653709182 @default.
• W2565370918 hasLocation W25653709183 @default.
• W2565370918 hasLocation W25653709184 @default.
• W2565370918 hasLocation W25653709185 @default.
• W2565370918 hasOpenAccess W2565370918 @default.
• W2565370918 hasPrimaryLocation W25653709181 @default.
• W2565370918 hasRelatedWork W2056002207 @default.
• W2565370918 hasRelatedWork W2288689888 @default.
• W2565370918 hasRelatedWork W2336435704 @default.
• W2565370918 hasRelatedWork W2357026567 @default.
• W2565370918 hasRelatedWork W2367461116 @default.
• W2565370918 hasRelatedWork W2374114645 @default.
• W2565370918 hasRelatedWork W2381460883 @default.
• W2565370918 hasRelatedWork W2471989939 @default.
• W2565370918 hasRelatedWork W2480785262 @default.
• W2565370918 hasRelatedWork W2936718154 @default.
• W2565370918 hasVolume "23" @default.
• W2565370918 isParatext "false" @default.

• next