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- W2565396588 abstract "To obtain basic knowledge about specific molecular mechanisms involved in the entry of pathogens into cells is the basis for establishing pharmacologic substances blocking initial viral binding, infection, and subsequent viral spread. Lack of information about key cellular factors involved in the initial steps of HBV infection has hampered the characterization of HBV binding and entry for decades. However, recently, the liver-specific sodium-dependent taurocholate cotransporting polypeptide (NTCP) has been discovered as a functional receptor for HBV and HDV, thus opening the field for new concepts of basic binding and entry of HBV and HDV. Here, we describe practical issues of a basic in vitro assay system to examine kinetics and mechanisms of receptor-dependent HBV binding, uptake, and intracellular trafficking by live-cell imaging confocal microscopy. The assay system is comprised of HepG2 cells expressing a NTCP-GFP fusion-protein and chemically synthesized, fluorophore-labeled part of HBV surface protein, spanning the first N-terminal 48 amino acids of preS1 of the large hepatitis B virus surface protein." @default.
- W2565396588 created "2017-01-06" @default.
- W2565396588 creator A5030711200 @default.
- W2565396588 creator A5031812055 @default.
- W2565396588 date "2016-12-15" @default.
- W2565396588 modified "2023-09-28" @default.
- W2565396588 title "Live Cell Imaging Confocal Microscopy Analysis of HBV Myr-PreS1 Peptide Binding and Uptake in NTCP-GFP Expressing HepG2 Cells" @default.
- W2565396588 cites W1571082748 @default.
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- W2565396588 doi "https://doi.org/10.1007/978-1-4939-6700-1_3" @default.
- W2565396588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27975305" @default.
- W2565396588 hasPublicationYear "2016" @default.
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