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- W2565414613 endingPage "105" @default.
- W2565414613 startingPage "98" @default.
- W2565414613 abstract "Foods and botanical supplements can interfere with the endocrine system through the presence of phytosteroids – chemicals that interact with steroids receptors. Phytoestrogens are well studied, but compounds such as kaempferol, apigenin, genistein, ginsenoside Rf, and glycyrrhetinic acid have been shown to interact with non-estrogen nuclear receptors. These compounds can have agonist, antagonist, or mixed agonist/antagonist activity depending on compound, receptor, cell line or tissue, and concentration. Some phytosteroids have also been shown to inhibit steroid metabolizing enzymes, resulting in biological effects through altered endogenous steroid concentrations. An interesting example, compound A (4-[1-chloro-2-(methylamino)ethyl]phenyl acetate hydrochloride (1:1)) is a promising selective glucocorticoid receptor modulator (SGRM) based on a phytosteroid isolated from Salsola tuberculatiformis Botschantzev. Given that $6.9 billion of herbal supplements are sold each year, is clear that further identification and characterization of phytosteroids is needed to ensure the safe and effective use of botanical supplements." @default.
- W2565414613 created "2017-01-06" @default.
- W2565414613 creator A5005766460 @default.
- W2565414613 creator A5068141324 @default.
- W2565414613 creator A5068626380 @default.
- W2565414613 date "2017-02-01" @default.
- W2565414613 modified "2023-10-10" @default.
- W2565414613 title "Phytosteroids beyond estrogens: Regulators of reproductive and endocrine function in natural products" @default.
- W2565414613 cites W142323669 @default.
- W2565414613 cites W144235401 @default.
- W2565414613 cites W1538221375 @default.
- W2565414613 cites W1595294120 @default.
- W2565414613 cites W1612254041 @default.
- W2565414613 cites W1841137100 @default.
- W2565414613 cites W1891260587 @default.
- W2565414613 cites W1953173033 @default.
- W2565414613 cites W1963927964 @default.
- W2565414613 cites W1965821089 @default.
- W2565414613 cites W1966962224 @default.
- W2565414613 cites W1968786809 @default.
- W2565414613 cites W1980296462 @default.
- W2565414613 cites W1980387889 @default.
- W2565414613 cites W1982412057 @default.
- W2565414613 cites W1982636068 @default.
- W2565414613 cites W1983745321 @default.
- W2565414613 cites W1984976414 @default.
- W2565414613 cites W1988683927 @default.
- W2565414613 cites W1993292496 @default.
- W2565414613 cites W1994903754 @default.
- W2565414613 cites W1995903208 @default.
- W2565414613 cites W1996131998 @default.
- W2565414613 cites W1996601414 @default.
- W2565414613 cites W1997736621 @default.
- W2565414613 cites W1998074968 @default.
- W2565414613 cites W2000217736 @default.
- W2565414613 cites W2003932891 @default.
- W2565414613 cites W2004738276 @default.
- W2565414613 cites W2012462612 @default.
- W2565414613 cites W2013362232 @default.
- W2565414613 cites W2018903703 @default.
- W2565414613 cites W2019144205 @default.
- W2565414613 cites W2019835784 @default.
- W2565414613 cites W2021789739 @default.
- W2565414613 cites W2031618333 @default.
- W2565414613 cites W2031752348 @default.
- W2565414613 cites W2033611758 @default.
- W2565414613 cites W2036451134 @default.
- W2565414613 cites W2039142173 @default.
- W2565414613 cites W2039921453 @default.
- W2565414613 cites W2045339251 @default.
- W2565414613 cites W2045534080 @default.
- W2565414613 cites W2045955842 @default.
- W2565414613 cites W2047131417 @default.
- W2565414613 cites W2056372790 @default.
- W2565414613 cites W2056751244 @default.
- W2565414613 cites W2057100665 @default.
- W2565414613 cites W2062911233 @default.
- W2565414613 cites W2065376743 @default.
- W2565414613 cites W2065507327 @default.
- W2565414613 cites W2067176980 @default.
- W2565414613 cites W2067877824 @default.
- W2565414613 cites W2067948296 @default.
- W2565414613 cites W2070603363 @default.
- W2565414613 cites W2071685912 @default.
- W2565414613 cites W2075884509 @default.
- W2565414613 cites W2076088414 @default.
- W2565414613 cites W2077112200 @default.
- W2565414613 cites W2077857833 @default.
- W2565414613 cites W2079130906 @default.
- W2565414613 cites W2081253923 @default.
- W2565414613 cites W2082763309 @default.
- W2565414613 cites W2084085275 @default.
- W2565414613 cites W2087445421 @default.
- W2565414613 cites W2089557515 @default.
- W2565414613 cites W2090222802 @default.
- W2565414613 cites W2093073704 @default.
- W2565414613 cites W2097221860 @default.
- W2565414613 cites W2103914520 @default.
- W2565414613 cites W211424878 @default.
- W2565414613 cites W2118964612 @default.
- W2565414613 cites W2123529223 @default.
- W2565414613 cites W2124121505 @default.
- W2565414613 cites W2125574822 @default.
- W2565414613 cites W2135268524 @default.
- W2565414613 cites W2136961882 @default.
- W2565414613 cites W2139185290 @default.
- W2565414613 cites W2142195202 @default.
- W2565414613 cites W2146292360 @default.
- W2565414613 cites W2148114970 @default.
- W2565414613 cites W2151665077 @default.
- W2565414613 cites W2153264091 @default.
- W2565414613 cites W2154345609 @default.
- W2565414613 cites W2155468326 @default.
- W2565414613 cites W2158138607 @default.
- W2565414613 cites W2159380877 @default.
- W2565414613 cites W2165101701 @default.
- W2565414613 cites W2168789122 @default.
- W2565414613 cites W2282798324 @default.