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- W2565434528 abstract "Purpose: Cervical cancer is one of the most common neoplastic diseases affecting women, with a combined worldwide incidence of almost half a million new cases. Polymorphisms in DNA repair genes may contribute the genetic instability and carcinogenesis. Methods & Materials: Cervical tissue derived from patients with cervical cancer (N = 138) and non-cancer controls (N = 180) were taken under informed consent. Genotyping for APE-I Glu 148 Asp polymorphism was performed by a PCR- CTPP as well as HPV type 16 and 118 was amplified by multiplex –PCR. Results: It has been observed that Asp/Glu with Glu/Glu genotypes that combined we observed statistically significant with protective effect for developing of cervix cancer (OR-0.51, 95% CI 0.31-0.83, p-0.006). The combined Asp/Glu with Glu/Glu genotypes who were using oral contraceptives were shown to be statistically significant with reduced risk of cervical cancer (OR-0.22 95% CI- 0.11-0.47, p-0.0002). It has been suggested that significantly correlation between HPV 16 and users of oral contraceptives in certain APE-1 genotypes with reduced risk in developing cervix cancer. Conclusion: We observed statistical significant association with reduced risk of cervix cancer in APE-1 with different genotypes, though, on the other hand, in association between HPV type 18 and those having SCC highly increased risk of cervical cancer was observed." @default.
- W2565434528 created "2017-01-06" @default.
- W2565434528 creator A5027654993 @default.
- W2565434528 date "2016-12-01" @default.
- W2565434528 modified "2023-09-25" @default.
- W2565434528 title "Association of genetic polymorphism of the DNA base excision repair gene (APE-1 Asp/148 Glu) and HPV type (16/18) with the risk of cervix cancer in north Indian population" @default.
- W2565434528 doi "https://doi.org/10.1016/j.ijid.2016.11.232" @default.
- W2565434528 hasPublicationYear "2016" @default.
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