Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565475617> ?p ?o ?g. }
- W2565475617 endingPage "285" @default.
- W2565475617 startingPage "279" @default.
- W2565475617 abstract "Reactive oxygen species (ROS) are normally produced during cell metabolism, there is strong evidence to suggest that ROS produced in excess impair the cell and may be etiologically related to various neurodegenerative diseases. This study was undertaken to examine the effects of Lepidium meyenii (MACA) methanol leaf extract on neurotoxicity in PC12 cell exposed to 6-hydroxydopamine (6-OHDA). Fresh samples of “maca” leaves were processed in order to obtain foliar extracts and to evaluate the neurobiological activity on PC12 cells, subjected to the cytotoxic effect of 6-OHDA through the determination of the capacity antioxidant, cell viability and cytotoxicity assays on PC12 cells. The results of the tests of antioxidant activity, showed maximum values of 2262.37 and 1305.36 expressed in Trolox equivalents (TEAC), for the methanolic and aqueous fractions respectively. Cell viability assays at a dose of 10 μg extract showed an increase of 31% and 60% at 6 and 12 h of pretreatment, respectively. Cytotoxicity assays at the same dose and exposure time showed a 31.4% and 47.8% reduction in lactate dehydrogenase (LDH) activity and an increase in superoxide dismutase (SOD) activity. The results allow us to affirm that the methanolic foliar extract of “maca” presents in vitro neurobiological activity of antioxidant protection, increase in cell viability and reduction of cytotoxicity against oxidative stress generated by 6-OHDA. In conclusion, the present study shows a protective role for Lepidium meyenii leaf extract on 6-OHDA-induced toxicity by an antioxidant effect." @default.
- W2565475617 created "2017-01-06" @default.
- W2565475617 creator A5003381310 @default.
- W2565475617 creator A5008503323 @default.
- W2565475617 creator A5010340733 @default.
- W2565475617 creator A5023124878 @default.
- W2565475617 creator A5032368064 @default.
- W2565475617 creator A5037413497 @default.
- W2565475617 creator A5074652382 @default.
- W2565475617 date "2017-01-08" @default.
- W2565475617 modified "2023-10-01" @default.
- W2565475617 title "Antioxidant and neuroprotector effect of <i>Lepidium meyenii</i> (maca) methanol leaf extract against 6-hydroxy dopamine (6-OHDA)-induced toxicity in PC12 cells" @default.
- W2565475617 cites W1522051947 @default.
- W2565475617 cites W1892641744 @default.
- W2565475617 cites W1977741386 @default.
- W2565475617 cites W1980171873 @default.
- W2565475617 cites W1992788138 @default.
- W2565475617 cites W2003352405 @default.
- W2565475617 cites W2011024431 @default.
- W2565475617 cites W2019034801 @default.
- W2565475617 cites W2044906861 @default.
- W2565475617 cites W2061719878 @default.
- W2565475617 cites W2070286407 @default.
- W2565475617 cites W2081218759 @default.
- W2565475617 cites W2085478193 @default.
- W2565475617 cites W2087428438 @default.
- W2565475617 cites W2091339607 @default.
- W2565475617 cites W2098921461 @default.
- W2565475617 cites W2118428213 @default.
- W2565475617 cites W2124397847 @default.
- W2565475617 cites W2142800498 @default.
- W2565475617 cites W2185348657 @default.
- W2565475617 cites W2240789667 @default.
- W2565475617 cites W2256665430 @default.
- W2565475617 cites W2464722857 @default.
- W2565475617 cites W2511634889 @default.
- W2565475617 cites W2514655937 @default.
- W2565475617 cites W2525795464 @default.
- W2565475617 cites W2539114298 @default.
- W2565475617 cites W2546380268 @default.
- W2565475617 cites W2548952489 @default.
- W2565475617 cites W2550922779 @default.
- W2565475617 cites W839840583 @default.
- W2565475617 doi "https://doi.org/10.1080/15376516.2016.1275908" @default.
- W2565475617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28007001" @default.
- W2565475617 hasPublicationYear "2017" @default.
- W2565475617 type Work @default.
- W2565475617 sameAs 2565475617 @default.
- W2565475617 citedByCount "16" @default.
- W2565475617 countsByYear W25654756172018 @default.
- W2565475617 countsByYear W25654756172019 @default.
- W2565475617 countsByYear W25654756172020 @default.
- W2565475617 countsByYear W25654756172021 @default.
- W2565475617 countsByYear W25654756172022 @default.
- W2565475617 crossrefType "journal-article" @default.
- W2565475617 hasAuthorship W2565475617A5003381310 @default.
- W2565475617 hasAuthorship W2565475617A5008503323 @default.
- W2565475617 hasAuthorship W2565475617A5010340733 @default.
- W2565475617 hasAuthorship W2565475617A5023124878 @default.
- W2565475617 hasAuthorship W2565475617A5032368064 @default.
- W2565475617 hasAuthorship W2565475617A5037413497 @default.
- W2565475617 hasAuthorship W2565475617A5074652382 @default.
- W2565475617 hasConcept C109316439 @default.
- W2565475617 hasConcept C1491633281 @default.
- W2565475617 hasConcept C178790620 @default.
- W2565475617 hasConcept C181199279 @default.
- W2565475617 hasConcept C185592680 @default.
- W2565475617 hasConcept C202751555 @default.
- W2565475617 hasConcept C2775838275 @default.
- W2565475617 hasConcept C2776151105 @default.
- W2565475617 hasConcept C2776231299 @default.
- W2565475617 hasConcept C2777318727 @default.
- W2565475617 hasConcept C2778004101 @default.
- W2565475617 hasConcept C2779491297 @default.
- W2565475617 hasConcept C2781401929 @default.
- W2565475617 hasConcept C29730261 @default.
- W2565475617 hasConcept C48349386 @default.
- W2565475617 hasConcept C53227056 @default.
- W2565475617 hasConcept C55493867 @default.
- W2565475617 hasConcept C86803240 @default.
- W2565475617 hasConcept C98274493 @default.
- W2565475617 hasConceptScore W2565475617C109316439 @default.
- W2565475617 hasConceptScore W2565475617C1491633281 @default.
- W2565475617 hasConceptScore W2565475617C178790620 @default.
- W2565475617 hasConceptScore W2565475617C181199279 @default.
- W2565475617 hasConceptScore W2565475617C185592680 @default.
- W2565475617 hasConceptScore W2565475617C202751555 @default.
- W2565475617 hasConceptScore W2565475617C2775838275 @default.
- W2565475617 hasConceptScore W2565475617C2776151105 @default.
- W2565475617 hasConceptScore W2565475617C2776231299 @default.
- W2565475617 hasConceptScore W2565475617C2777318727 @default.
- W2565475617 hasConceptScore W2565475617C2778004101 @default.
- W2565475617 hasConceptScore W2565475617C2779491297 @default.
- W2565475617 hasConceptScore W2565475617C2781401929 @default.
- W2565475617 hasConceptScore W2565475617C29730261 @default.
- W2565475617 hasConceptScore W2565475617C48349386 @default.
- W2565475617 hasConceptScore W2565475617C53227056 @default.
- W2565475617 hasConceptScore W2565475617C55493867 @default.