FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565537108> ?p ?o ?g. }

• W2565537108 endingPage "26" @default.
• W2565537108 startingPage "17" @default.
• W2565537108 abstract "Abstract OBJECTIVE To determine plasma drug concentrations after IV administration of a bolus followed by continuous rate infusion (CRI) of sodium benzylpenicillin and ceftiofur sodium to healthy adult horses. ANIMALS 6 Thoroughbred mares (3 to 9 years old; mean ± SD body weight, 544 ± 55 kg) with no history of recent antimicrobial treatment. PROCEDURES Horses were used in 2 experiments conducted 14 days apart. For each experiment, horses were housed individually in stables, and catheters were placed bilaterally in both jugular veins for drug administration by CRI (left catheter) and for intermittent collection of blood samples (right catheter). Synovial fluid samples were obtained from carpal joints following ceftiofur administration to evaluate drug diffusion into articular spaces. RESULTS Plasma concentrations above accepted minimum inhibitory concentrations for common pathogens of horses were achieved within 1 minute after bolus administration and remained above the minimum inhibitory concentration for 48 (ceftiofur) or 12 (benzylpenicillin) hours (ie, the duration of the CRI). Mean synovial fluid ceftiofur free acid equivalent concentrations were approximately 46% (range, 25.4% to 59.8%) of plasma concentrations at the end of infusion. CONCLUSIONS AND CLINICAL RELEVANCE Compared with intermittent bolus administration, the loading dose and CRI used less drug but maintained high plasma concentrations for the duration of infusion. By use of pharmacological parameters derived in this study, a loading dose of 2.5 mg/kg and CRI of 200 μg/kg/h should achieve plasma ceftiofur concentrations of 4 μg/mL; a loading dose and CRI of 1.3 mg/kg and 2.5 μg/kg/h, respectively, should achieve plasma benzylpenicillin concentrations of 2 μg/mL." @default.
• W2565537108 created "2017-01-06" @default.
• W2565537108 creator A5021472716 @default.
• W2565537108 creator A5029403439 @default.
• W2565537108 creator A5059901404 @default.
• W2565537108 creator A5065208291 @default.
• W2565537108 creator A5086333117 @default.
• W2565537108 date "2017-01-01" @default.
• W2565537108 modified "2023-10-16" @default.
• W2565537108 title "Pharmacokinetics of intravenous continuous rate infusions of sodium benzylpenicillin and ceftiofur sodium in adult horses" @default.
• W2565537108 cites W121154348 @default.
• W2565537108 cites W1527826646 @default.
• W2565537108 cites W1560697614 @default.
• W2565537108 cites W1583540321 @default.
• W2565537108 cites W1699591744 @default.
• W2565537108 cites W1909817355 @default.
• W2565537108 cites W1929224159 @default.
• W2565537108 cites W1965725897 @default.
• W2565537108 cites W1970400998 @default.
• W2565537108 cites W1972858790 @default.
• W2565537108 cites W1981568603 @default.
• W2565537108 cites W1984161829 @default.
• W2565537108 cites W1985794881 @default.
• W2565537108 cites W1991802030 @default.
• W2565537108 cites W2002916954 @default.
• W2565537108 cites W2013452629 @default.
• W2565537108 cites W2016888150 @default.
• W2565537108 cites W2017338716 @default.
• W2565537108 cites W2021684384 @default.
• W2565537108 cites W2052252521 @default.
• W2565537108 cites W2057226149 @default.
• W2565537108 cites W2060184652 @default.
• W2565537108 cites W2062495428 @default.
• W2565537108 cites W2074365649 @default.
• W2565537108 cites W2086021778 @default.
• W2565537108 cites W2087706018 @default.
• W2565537108 cites W2097898411 @default.
• W2565537108 cites W2113717321 @default.
• W2565537108 cites W2123435197 @default.
• W2565537108 cites W2131237484 @default.
• W2565537108 cites W2136295261 @default.
• W2565537108 cites W2138471823 @default.
• W2565537108 cites W2140467366 @default.
• W2565537108 cites W2146537795 @default.
• W2565537108 cites W2148379092 @default.
• W2565537108 cites W2158308518 @default.
• W2565537108 cites W2166840599 @default.
• W2565537108 cites W4231421929 @default.
• W2565537108 doi "https://doi.org/10.2460/ajvr.78.1.17" @default.
• W2565537108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28029281" @default.
• W2565537108 hasPublicationYear "2017" @default.
• W2565537108 type Work @default.
• W2565537108 sameAs 2565537108 @default.
• W2565537108 citedByCount "1" @default.
• W2565537108 countsByYear W25655371082019 @default.
• W2565537108 crossrefType "journal-article" @default.
• W2565537108 hasAuthorship W2565537108A5021472716 @default.
• W2565537108 hasAuthorship W2565537108A5029403439 @default.
• W2565537108 hasAuthorship W2565537108A5059901404 @default.
• W2565537108 hasAuthorship W2565537108A5065208291 @default.
• W2565537108 hasAuthorship W2565537108A5086333117 @default.
• W2565537108 hasConcept C112705442 @default.
• W2565537108 hasConcept C126322002 @default.
• W2565537108 hasConcept C151730666 @default.
• W2565537108 hasConcept C174802600 @default.
• W2565537108 hasConcept C185592680 @default.
• W2565537108 hasConcept C2776341680 @default.
• W2565537108 hasConcept C2780122547 @default.
• W2565537108 hasConcept C2780762169 @default.
• W2565537108 hasConcept C42219234 @default.
• W2565537108 hasConcept C43376680 @default.
• W2565537108 hasConcept C501593827 @default.
• W2565537108 hasConcept C55493867 @default.
• W2565537108 hasConcept C64778159 @default.
• W2565537108 hasConcept C71924100 @default.
• W2565537108 hasConcept C86803240 @default.
• W2565537108 hasConcept C98274493 @default.
• W2565537108 hasConceptScore W2565537108C112705442 @default.
• W2565537108 hasConceptScore W2565537108C126322002 @default.
• W2565537108 hasConceptScore W2565537108C151730666 @default.
• W2565537108 hasConceptScore W2565537108C174802600 @default.
• W2565537108 hasConceptScore W2565537108C185592680 @default.
• W2565537108 hasConceptScore W2565537108C2776341680 @default.
• W2565537108 hasConceptScore W2565537108C2780122547 @default.
• W2565537108 hasConceptScore W2565537108C2780762169 @default.
• W2565537108 hasConceptScore W2565537108C42219234 @default.
• W2565537108 hasConceptScore W2565537108C43376680 @default.
• W2565537108 hasConceptScore W2565537108C501593827 @default.
• W2565537108 hasConceptScore W2565537108C55493867 @default.
• W2565537108 hasConceptScore W2565537108C64778159 @default.
• W2565537108 hasConceptScore W2565537108C71924100 @default.
• W2565537108 hasConceptScore W2565537108C86803240 @default.
• W2565537108 hasConceptScore W2565537108C98274493 @default.
• W2565537108 hasIssue "1" @default.
• W2565537108 hasLocation W25655371081 @default.
• W2565537108 hasLocation W25655371082 @default.
• W2565537108 hasOpenAccess W2565537108 @default.
• W2565537108 hasPrimaryLocation W25655371081 @default.

• next