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• W2565602430 abstract "Abstract Keeping in mind the contemporary environmental concern raised over the disposal of surfactants into water bodies, we synthesized biodegradable cationic gemini surfactant ethane-1,2-diyl bis(N,N-dimethyl-N-hexadecylammoniumacetoxy) dichloride (16-E2-16), which bears easily cleavable ester functionalities (betaine type arrangement) in its spacer. This research article encompasses an in vitro analysis of the interaction between the synthesized gemini surfactant and a serum transport protein, porcine serum albumin (PSA) under physiological mimetic conditions. A multi-technique approach was exploited to explore the structural alterations induced in PSA at different concentrations of 16-E2-16. Fluorescence measurements unraveled a substantial interaction between PSA and 16-E2-16 (Kb ∼ 104 M−1). Synchronous and three-dimensional fluorescence spectra further validated the binding of 16-E2-16 with PSA. Pyrene emission fluorescence depicted an increased hydrophilicity experienced by the probe molecules on account of their expulsion into the solvent due to a comparatively stronger binding of the gemini surfactant with PSA. The UV–vis studies established the ground state complexation of the gemini with PSA. Interestingly, far-UV CD results demonstrated the stabilization of secondary structure of PSA at concentrations below and above the CMC of 16-E2-16. Near-UV CD spectra revealed negligible changes in the tertiary structure of PSA. Additonally, CV scans depicted electrochemically inactive 16-E2-16−PSA complex formation and thus reinforced the findings of spectroscopic investigations. Overall, it is inferred that 16-E2-16 binds efficiently with PSA affecting both its microenvironment and conformation. Owing to these favorable interactions, 16-E2-16 may find its application as a prospective excipient in drug, skincare and immunoassay reagent formulations, in which serum albumins are frequently used." @default.
• W2565602430 created "2017-01-06" @default.
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• W2565602430 date "2017-03-01" @default.
• W2565602430 modified "2023-09-23" @default.
• W2565602430 title "An ester-functionalized cationic gemini surfactant mediated structural transitions of porcine serum albumin (PSA) via binding interaction" @default.
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• W2565602430 doi "https://doi.org/10.1016/j.colsurfa.2016.12.028" @default.
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