Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565607198> ?p ?o ?g. }
- W2565607198 endingPage "355" @default.
- W2565607198 startingPage "343" @default.
- W2565607198 abstract "Midostaurin is a multikinase inhibitor that inhibits receptor tyrosine kinases (Flt3, CD117/c-kit, platelet-derived growth factor receptor, vascular endothelial growth factor receptor 2) as well as non-receptor tyrosine kinases (Frg, Src, Syk, Protein kinase C). Combination of midostaurin with conventional intensive chemotherapy followed by one year maintenance monotherapy was recently reported to improve the survival of acute myeloid leukemia (AML) patients with Flt3 mutations. Areas covered: Relevant publications were identified through literature searches in the PubMed database. We searched for (i) original articles describing the results from clinical studies; (ii) published articles describing the importance of midostaurin-inhibited kinases for leukemogenesis and chemosensitivity. Expert opinion: Midostaurin monotherapy is well tolerated, combined with conventional chemotherapy gastrointestinal toxicity increases significantly. Midostaurin alters anthracycline pharmacokinetics. Furthermore, its antileukemic effects may not only be mediated through Flt3 inhibition alone; the inhibition of other kinases may also be important for the overall antileukemic effect. Midostaurin may then have direct effects on the leukemic cells but also indirect antileukemic effects through inhibition of the AML-supporting effects of neighboring stromal cells in the bone marrow microenvironment. Midostaurin may thus be used in combination with intensive chemotherapy, as maintenance treatment or as disease-stabilizing treatment for elderly unfit patients." @default.
- W2565607198 created "2017-01-06" @default.
- W2565607198 creator A5021294750 @default.
- W2565607198 creator A5053862074 @default.
- W2565607198 creator A5063670142 @default.
- W2565607198 date "2016-12-28" @default.
- W2565607198 modified "2023-10-05" @default.
- W2565607198 title "Antileukemic effects of midostaurin in acute myeloid leukemia – the possible importance of multikinase inhibition in leukemic as well as nonleukemic stromal cells" @default.
- W2565607198 cites W131684426 @default.
- W2565607198 cites W135651168 @default.
- W2565607198 cites W1480483651 @default.
- W2565607198 cites W1600365609 @default.
- W2565607198 cites W1613258091 @default.
- W2565607198 cites W1728550488 @default.
- W2565607198 cites W1744167954 @default.
- W2565607198 cites W1763573378 @default.
- W2565607198 cites W1772965091 @default.
- W2565607198 cites W1782544073 @default.
- W2565607198 cites W1920420607 @default.
- W2565607198 cites W1937648101 @default.
- W2565607198 cites W1965027324 @default.
- W2565607198 cites W1965436367 @default.
- W2565607198 cites W1966023928 @default.
- W2565607198 cites W1968611056 @default.
- W2565607198 cites W1969481020 @default.
- W2565607198 cites W1973474763 @default.
- W2565607198 cites W1976058906 @default.
- W2565607198 cites W1988047797 @default.
- W2565607198 cites W1990715913 @default.
- W2565607198 cites W1992261162 @default.
- W2565607198 cites W1993300766 @default.
- W2565607198 cites W2003336769 @default.
- W2565607198 cites W2005400731 @default.
- W2565607198 cites W2009069027 @default.
- W2565607198 cites W2009816863 @default.
- W2565607198 cites W2012791599 @default.
- W2565607198 cites W2014478679 @default.
- W2565607198 cites W2015867957 @default.
- W2565607198 cites W2020930633 @default.
- W2565607198 cites W2021759592 @default.
- W2565607198 cites W2022108422 @default.
- W2565607198 cites W2031864496 @default.
- W2565607198 cites W2035673396 @default.
- W2565607198 cites W2037154482 @default.
- W2565607198 cites W2039193492 @default.
- W2565607198 cites W2044308979 @default.
- W2565607198 cites W2049709955 @default.
- W2565607198 cites W2051380481 @default.
- W2565607198 cites W2051815726 @default.
- W2565607198 cites W2053074474 @default.
- W2565607198 cites W2053690380 @default.
- W2565607198 cites W2053715974 @default.
- W2565607198 cites W2054466658 @default.
- W2565607198 cites W2057939330 @default.
- W2565607198 cites W2058188568 @default.
- W2565607198 cites W2060778522 @default.
- W2565607198 cites W2062012261 @default.
- W2565607198 cites W2065197757 @default.
- W2565607198 cites W2070099778 @default.
- W2565607198 cites W2071111320 @default.
- W2565607198 cites W2076971387 @default.
- W2565607198 cites W2080059445 @default.
- W2565607198 cites W2081003976 @default.
- W2565607198 cites W2081021661 @default.
- W2565607198 cites W2082620735 @default.
- W2565607198 cites W2083614603 @default.
- W2565607198 cites W2085642575 @default.
- W2565607198 cites W2086402500 @default.
- W2565607198 cites W2088065829 @default.
- W2565607198 cites W2089353165 @default.
- W2565607198 cites W2089471687 @default.
- W2565607198 cites W2098489098 @default.
- W2565607198 cites W2099377536 @default.
- W2565607198 cites W2101095291 @default.
- W2565607198 cites W2101935191 @default.
- W2565607198 cites W2103827225 @default.
- W2565607198 cites W2108401821 @default.
- W2565607198 cites W2108753267 @default.
- W2565607198 cites W2109396389 @default.
- W2565607198 cites W2110121929 @default.
- W2565607198 cites W2111251689 @default.
- W2565607198 cites W2112414163 @default.
- W2565607198 cites W2121528425 @default.
- W2565607198 cites W2125816527 @default.
- W2565607198 cites W2131603280 @default.
- W2565607198 cites W2131862838 @default.
- W2565607198 cites W2135031820 @default.
- W2565607198 cites W2139928380 @default.
- W2565607198 cites W2140146894 @default.
- W2565607198 cites W2144114332 @default.
- W2565607198 cites W2150744959 @default.
- W2565607198 cites W2153345005 @default.
- W2565607198 cites W2154625299 @default.
- W2565607198 cites W2154742235 @default.
- W2565607198 cites W2155214429 @default.
- W2565607198 cites W2155696324 @default.
- W2565607198 cites W2156167564 @default.
- W2565607198 cites W2156645168 @default.