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• W2565614510 abstract "In our previous studies we showed antitumor and anti-inflammatory activities of protein kinases inhibitor pyrrol derivate 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2,5-dione (MI-1) on rat colon cancer model. Therefore anti-inflammatory effect of MI-1 on rat acetic acid induced ulcerative colitis (UC) model was aimed to be discovered. The anti-inflammatory effects of MI-1 (2.7 mg/kg daily) compared to reference drug Prednisolone (0.7 mg/kg daily) after 14-day usage were evaluated on macro- and light microscopy levels and expressed in 21-grade scale. Redox status of bowel mucosa was also estimated. It was shown that in UC group the grade of total injury (GTI) was equal to 9.6 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:msub><mml:mrow><mml:mi mathvariant=normal>G</mml:mi><mml:mi mathvariant=normal>T</mml:mi><mml:mi mathvariant=normal>I</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>c</mml:mi><mml:mi mathvariant=normal>o</mml:mi><mml:mi mathvariant=normal>n</mml:mi><mml:mi mathvariant=normal>t</mml:mi><mml:mi mathvariant=normal>r</mml:mi><mml:mi mathvariant=normal>o</mml:mi><mml:mi mathvariant=normal>l</mml:mi></mml:mrow></mml:msub><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0</mml:mn></mml:math>). Increase of malonic dialdehyde (MDA) by 89% and protein carbonyl groups (PCG) by 60% and decrease of superoxide dismutase (SOD) by 40% were also observed. Prednisolone decreased GTI to 3 and leveled SOD activity, but MDA and PCG remained higher than control ones by 52% and 42%, respectively. MI-1 restored colon mucosa integrity and decreased mucosa inflammation down to GTI = 0.5 and leveled PCG and SOD. Thus, MI-1 possessed anti-inflammatory properties, which were more expressed that Prednisolone ones, as well as normalized mucosa redox balance, and so has a prospect for correction of inflammatory processes." @default.
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• W2565614510 date "2016-01-01" @default.
• W2565614510 modified "2023-10-16" @default.
• W2565614510 title "Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate" @default.
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• W2565614510 doi "https://doi.org/10.1155/2016/2145753" @default.
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