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- W2565628176 abstract "e19656 Background: Nearly 50% of NSCLC patients (pts) are age 70 or over but only a few of them receive treatment. The results of CGA for elderly NSCLC cancer pts receiving chemotherapy were analyzed to investigate the correlation between each CGA domain and development of severe toxicity. Methods: A total of 131 NSCLC pts ≥ 65 years with stage IIIb/IV disease were treated with either monotherapy of vinorelbine (n=3) or docetaxel (n=1) or pemetrexed (n=28) or gemcitabine (n=31) or erlotinib (n=36) or the gemcitabine plus docetaxel combination (n=32). At baseline, CGA was performed using the following instruments: Cumulative Illness Rating Scale-Geriatrics (CIRS-G), Activities of Daily Living (ADL), Instrumental Activities of Daily Living (IADL), Mini-Mental State Examination (MMSE) and Geriatric Depression Score (GDS-15). Toxicity was scored using NCI-CTC v2. Results: Median age was 74 years (range 65-92). Treatment was 1st-line for 51% of pts. Single-agent treatment was administered to 65% of pts and 28% of pts received erlotinib. Performance status was 0 in 27%, 1 in 56% and 2 in 17% of pts. Median (range) baseline CGA scores were as follows: ADL 6, IADL 7 (0-8), CIRS-G 3.0 (0-24), grade 3-4 CIRS-G 0 (0-3), MMSE 28 (16-30), GDS 5 (0-13). Overall, grade 3-4 neutropenia occurred in 4% of pts, grade 2-3 anemia in 20%, grade 3-4 thrombocytopenia in 1% and any non-hematologic grade 3-4 toxicity in 6% of pts. None of the CGA scores were significantly associated with the occurrence of severe toxicity. Conclusions: Baseline CGA does not predict severe toxicity in elderly NCSLC pts receiving chemotherapy. Correlations between CGA domains and toxicity (p values shown). Neutropenia grade 3-4 Anemia grade 2-3 Thrombocytopenia grade 3-4 Any nonhematologic grade 3-4 IADL 7-8 vs <7 0.851 0.045 0.430 0.724 MMSE <24 vs ≥24 0.261 0.783 0.200 0.201 GDS ≤5 vs >5 0.999 0.638 0.999 0.433 CIRS-G grade 3-4 0 vs ≥1 0.999 0.802 0.364 0.703" @default.
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- W2565628176 date "2011-05-20" @default.
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- W2565628176 title "Baseline comprehensive geriatric assessment (CGA) and prediction of toxicity in elderly non-small cell lung cancer (NSCLC) patients receiving chemotherapy." @default.
- W2565628176 doi "https://doi.org/10.1200/jco.2011.29.15_suppl.e19656" @default.
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