Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565643793> ?p ?o ?g. }
- W2565643793 abstract "A series of iminopyridine platinum chelate compounds has been prepared and characterized by NMR spectroscopy and single-crystal X-ray diffraction. The complexes were evaluated in C6 tumoral cells as an in vitro model for glioblastoma multiforme. The DNA-binding properties of these complexes were studied by UV-Vis absorption and fluorescence spectroscopy and Density Functional Theory calculations were performed in an effort to rationalize the observed properties at the molecular level. The most promising drug candidate displayed a similar potency in inducing cell death to the clinically used reference compound and showed significant inhibition of glioblastoma cell proliferation. Moreover, this compound had a safer profile than cisplatin on non-tumoral cells." @default.
- W2565643793 created "2017-01-06" @default.
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- W2565643793 date "2017-03-01" @default.
- W2565643793 modified "2023-10-15" @default.
- W2565643793 title "Synthesis, characterization, DNA interactions and antiproliferative activity on glioblastoma of iminopyridine platinum(II) chelate complexes" @default.
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- W2565643793 doi "https://doi.org/10.1016/j.jinorgbio.2016.11.032" @default.
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- W2565643793 hasPublicationYear "2017" @default.
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