Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565651301> ?p ?o ?g. }
- W2565651301 abstract "Abstract The pleiotropic activities of TNF are mediated by two structurally related but functionally distinct type I transmembrane receptors, p55TNFR and p75TNFR expressed in most cell types, that can be cleaved and act as TNF scavengers. Here, we investigated the effect of persistent p55TNFR cell surface expression during aerosol inhalation challenge with virulent M. tuberculosis H37Rv. We demonstrated that persistency of p55TNFR in macrophage cultures increased the synthesis of soluble TNF, p75TNFR and NO, however, had no effects on bacteria killing ability. Furthermore, it did not facilitate enhanced protection to primary acute M. tuberculosis infection in p55 ∆NS mice. Without exacerbated lung inflammation, we found a compensatory increase in p75TNFR shedding and decrease in bioactive TNF in BAL of p55 ∆NS mice after M. tuberculosis challenge. Defective expressions of CD44 and INFγ attributed to an impaired T cell response during persistent p55TNFR expression that caused marginal transient susceptibility during chronic infection. Moreover, persistent p55TNFR expression induced early reactivation during latent tuberculosis infection. These data indicate a prominent role of p55TNFR shedding in Th1 mediated protection against chronic and latent tuberculosis infection." @default.
- W2565651301 created "2017-01-06" @default.
- W2565651301 creator A5000840581 @default.
- W2565651301 creator A5013297113 @default.
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- W2565651301 creator A5028725144 @default.
- W2565651301 creator A5061593414 @default.
- W2565651301 creator A5080522389 @default.
- W2565651301 creator A5090058596 @default.
- W2565651301 date "2016-12-20" @default.
- W2565651301 modified "2023-09-25" @default.
- W2565651301 title "Persistent p55TNFR expression impairs T cell responses during chronic tuberculosis and promotes reactivation" @default.
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- W2565651301 doi "https://doi.org/10.1038/srep39499" @default.
- W2565651301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5171238" @default.
- W2565651301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27995986" @default.
- W2565651301 hasPublicationYear "2016" @default.
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