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- W2565676007 abstract "Author(s): Fu, Catherine Yarou | Advisor(s): VanBrocklin, Henry | Abstract: The exquisite specificity and affinity for their target antigens makes radiolabeled antibodies attractive candidates for therapeutics and drug delivery agents. The aim of this study was to evaluate the potential utility of two clinically available antibodies, Certolizumab Pegol (Cimzia) and Pembrolizumab (Pembro) for immuno-PET imaging. Methods: Antibodies pembrolizumab and certolizuman pegol were labeled with 89Zr in high chemical and radiochemical purity. Results: 89Zr-DFO-Pembro and 89Zr-DFO-Cimzia have been prepared with high radiochemical purity (g95%) with good radiochemical yield (~70%). Conclusion: Results from this studies will provide requisite data for an IND submission to the FDA and ultimately clinical translation of 89Zr-DFO-Pembro and 89Zr-DFO-Cimzia." @default.
- W2565676007 created "2017-01-06" @default.
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- W2565676007 date "2016-01-01" @default.
- W2565676007 modified "2023-09-27" @default.
- W2565676007 title "Translation of Zirconium-89 labeled Antibodies for Human Imaging" @default.
- W2565676007 hasPublicationYear "2016" @default.
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