FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565720563> ?p ?o ?g. }

• W2565720563 endingPage "624" @default.
• W2565720563 startingPage "616" @default.
• W2565720563 abstract "Abstract Lentigo maligna ( LM ) is an in situ variant of melanoma. Our objective was to systematically review clinical and histological clearance and recurrence rates of imiquimod treatment of LM with emphasis on progression to lentigo maligna melanoma ( LMM ). PubMed, EMBASE and the Cochrane library were searched from inception to May 2015. Articles were included if they described histologically proven LM treated with imiquimod 5% monotherapy or combined with another topical therapy. Analysed outcomes were clinical and histological clearance, recurrence rates and number of LMM . The quality was assessed using the GRADE ‐like checklist, and results were reported according to the PRISMA Statement. Twenty‐six case reports, 11 retrospective studies, three prospective studies and one randomized controlled trial were included. One case report of poor quality was excluded. Complete clinical clearance was seen in 369 of 471 patients (78.3%). Histological clearance was present in 285 of 370 (77%) patients. LMM was diagnosed in nine (1.8%) patients 3.9 months (range 0–11 months) post‐treatment. Univariate multinominal logistic regression showed that 6–7 applications/week had a 6.47 greater odds ( P = 0.017) of resulting in complete clinical clearance compared to 1–4 applications/week. An intensity of 6–7 applications/week showed a 8.85 greater odds ( P = 0.003) of resulting in histological clearance compared to 1–4 applications. Applying imiquimod >60 times during a treatment period of 12 weeks (range 4–36) showed a 7.75 greater odds ( P = 0.001) of resulting in histological clearance compared to <60 total applications. In conclusion, a treatment schedule using imiquimod 6–7 applications per week, with at least 60 applications, shows the greatest odds of complete clinical and histological clearance of LM . Imiquimod is an option for patients unfit for or not willing to undergo surgery or radiotherapy. Nine cases of LM progressed to LMM shortly after treatment. Our hypothesis is that these LMM may have been present before starting imiquimod." @default.
• W2565720563 created "2017-01-06" @default.
• W2565720563 creator A5012861929 @default.
• W2565720563 creator A5029129546 @default.
• W2565720563 creator A5041086406 @default.
• W2565720563 creator A5046706952 @default.
• W2565720563 creator A5066016182 @default.
• W2565720563 creator A5071014641 @default.
• W2565720563 date "2017-01-23" @default.
• W2565720563 modified "2023-10-11" @default.
• W2565720563 title "A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma: need for standardization of treatment schedule and outcome measures" @default.
• W2565720563 cites W1725569650 @default.
• W2565720563 cites W1798923641 @default.
• W2565720563 cites W1967641400 @default.
• W2565720563 cites W1975839045 @default.
• W2565720563 cites W1981347819 @default.
• W2565720563 cites W1983048434 @default.
• W2565720563 cites W1985846325 @default.
• W2565720563 cites W1990749703 @default.
• W2565720563 cites W1992094348 @default.
• W2565720563 cites W1998124379 @default.
• W2565720563 cites W1999727740 @default.
• W2565720563 cites W2000559124 @default.
• W2565720563 cites W2004260340 @default.
• W2565720563 cites W2008853666 @default.
• W2565720563 cites W2011851235 @default.
• W2565720563 cites W2013772581 @default.
• W2565720563 cites W2014982216 @default.
• W2565720563 cites W2017068868 @default.
• W2565720563 cites W2021106922 @default.
• W2565720563 cites W2023289486 @default.
• W2565720563 cites W2023728596 @default.
• W2565720563 cites W2028575017 @default.
• W2565720563 cites W2032690873 @default.
• W2565720563 cites W2037850155 @default.
• W2565720563 cites W2046726846 @default.
• W2565720563 cites W2047685052 @default.
• W2565720563 cites W2052162054 @default.
• W2565720563 cites W2054490089 @default.
• W2565720563 cites W2055501079 @default.
• W2565720563 cites W2059112084 @default.
• W2565720563 cites W2075626043 @default.
• W2565720563 cites W2089039313 @default.
• W2565720563 cites W2090283325 @default.
• W2565720563 cites W2093902734 @default.
• W2565720563 cites W2101464127 @default.
• W2565720563 cites W2106073417 @default.
• W2565720563 cites W2109367399 @default.
• W2565720563 cites W2121974005 @default.
• W2565720563 cites W2126972803 @default.
• W2565720563 cites W2132802507 @default.
• W2565720563 cites W2139366750 @default.
• W2565720563 cites W2154835971 @default.
• W2565720563 cites W2159033023 @default.
• W2565720563 cites W2159842335 @default.
• W2565720563 cites W2162864739 @default.
• W2565720563 cites W2165489060 @default.
• W2565720563 cites W2166621159 @default.
• W2565720563 cites W2180139687 @default.
• W2565720563 cites W2321811486 @default.
• W2565720563 cites W2395477731 @default.
• W2565720563 cites W2407690411 @default.
• W2565720563 cites W2471829242 @default.
• W2565720563 cites W3022903699 @default.
• W2565720563 cites W3023662983 @default.
• W2565720563 cites W4239525303 @default.
• W2565720563 doi "https://doi.org/10.1111/jdv.14085" @default.
• W2565720563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27987308" @default.
• W2565720563 hasPublicationYear "2017" @default.
• W2565720563 type Work @default.
• W2565720563 sameAs 2565720563 @default.
• W2565720563 citedByCount "57" @default.
• W2565720563 countsByYear W25657205632017 @default.
• W2565720563 countsByYear W25657205632018 @default.
• W2565720563 countsByYear W25657205632019 @default.
• W2565720563 countsByYear W25657205632020 @default.
• W2565720563 countsByYear W25657205632021 @default.
• W2565720563 countsByYear W25657205632022 @default.
• W2565720563 countsByYear W25657205632023 @default.
• W2565720563 crossrefType "journal-article" @default.
• W2565720563 hasAuthorship W2565720563A5012861929 @default.
• W2565720563 hasAuthorship W2565720563A5029129546 @default.
• W2565720563 hasAuthorship W2565720563A5041086406 @default.
• W2565720563 hasAuthorship W2565720563A5046706952 @default.
• W2565720563 hasAuthorship W2565720563A5066016182 @default.
• W2565720563 hasAuthorship W2565720563A5071014641 @default.
• W2565720563 hasConcept C126322002 @default.
• W2565720563 hasConcept C141071460 @default.
• W2565720563 hasConcept C156957248 @default.
• W2565720563 hasConcept C16005928 @default.
• W2565720563 hasConcept C2777264407 @default.
• W2565720563 hasConcept C2777393561 @default.
• W2565720563 hasConcept C2777658100 @default.
• W2565720563 hasConcept C2779112978 @default.
• W2565720563 hasConcept C502942594 @default.
• W2565720563 hasConcept C71924100 @default.
• W2565720563 hasConceptScore W2565720563C126322002 @default.
• W2565720563 hasConceptScore W2565720563C141071460 @default.

• next