FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565767544> ?p ?o ?g. }

• W2565767544 endingPage "1174" @default.
• W2565767544 startingPage "1166" @default.
• W2565767544 abstract "Abstract Cell‐based therapies using self‐beating cardiomyocytes have been attracting great attention for use in cardiac regeneration, although an effective procedure to improve cardiac differentiation and self‐beating induction is required. The purpose of this study is to clarify the effect of the culture substrate on cardiac maturation by separately evaluating the cardiac differentiation step and the beating induction step in vitro. To this end, the well‐studied cardiomyocyte‐like progenitor cell line P19CL6 and neonatal cardiomyocytes (NCMs) were selected and cultured on substrates coated with collagen type I (Col‐I), gelatin (Gel), fibronectin (FN), or poly‐ l ‐lysine (PLL). It was found that the cardiac differentiation step, which was assessed using cardiac marker gene expression (GATA‐binding protein 4 (GATA4), myocyte‐specific enhancer factor 2D (MEF2D), and hyperpolarization‐activated cyclic nucleotide‐gated potassium channel 4 (HCN4)) in the P19CL6 embryonal carcinoma cells, was greatly enhanced on Col‐I, Gel, and PLL. In contrast, the spontaneous beating step, which was directly assessed by counting the beating colonies and measuring contractile protein gene expression (α‐myosin heavy chain (α‐MHC), troponin C type 1 (TnC1), and troponin T type 2 (TnT2)) in the rat NCMs, was enhanced on the FN and PLL surfaces. In the present study, for the first time, it was found that PLL enhances both the cardiac differentiation and the beating induction steps of cardiac maturation, which can aid in preparing beating cardiomyocytes for regenerative medicine. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1166–1174, 2017." @default.
• W2565767544 created "2017-01-06" @default.
• W2565767544 creator A5004333023 @default.
• W2565767544 creator A5010308877 @default.
• W2565767544 creator A5028320463 @default.
• W2565767544 creator A5029930261 @default.
• W2565767544 creator A5035541028 @default.
• W2565767544 creator A5044198759 @default.
• W2565767544 creator A5058240973 @default.
• W2565767544 creator A5062735829 @default.
• W2565767544 creator A5066291847 @default.
• W2565767544 date "2017-02-11" @default.
• W2565767544 modified "2023-10-14" @default.
• W2565767544 title "Individual evaluation of cardiac marker expression and self-beating during cardiac differentiation of P19CL6 cells on different culture substrates" @default.
• W2565767544 cites W1537459781 @default.
• W2565767544 cites W1963756072 @default.
• W2565767544 cites W1968049796 @default.
• W2565767544 cites W1970288681 @default.
• W2565767544 cites W1970826251 @default.
• W2565767544 cites W1971366053 @default.
• W2565767544 cites W1975043059 @default.
• W2565767544 cites W1987568997 @default.
• W2565767544 cites W1988139909 @default.
• W2565767544 cites W1994387772 @default.
• W2565767544 cites W2002963491 @default.
• W2565767544 cites W2005264220 @default.
• W2565767544 cites W200601437 @default.
• W2565767544 cites W2006850788 @default.
• W2565767544 cites W2010435716 @default.
• W2565767544 cites W2015181454 @default.
• W2565767544 cites W2015364856 @default.
• W2565767544 cites W2028036560 @default.
• W2565767544 cites W2029104324 @default.
• W2565767544 cites W2039473936 @default.
• W2565767544 cites W2053736927 @default.
• W2565767544 cites W2055323054 @default.
• W2565767544 cites W2058525629 @default.
• W2565767544 cites W2058657693 @default.
• W2565767544 cites W2064809128 @default.
• W2565767544 cites W2065168340 @default.
• W2565767544 cites W2066889072 @default.
• W2565767544 cites W2067249190 @default.
• W2565767544 cites W2067591094 @default.
• W2565767544 cites W2068637372 @default.
• W2565767544 cites W2070474795 @default.
• W2565767544 cites W2074520685 @default.
• W2565767544 cites W2074880108 @default.
• W2565767544 cites W2079042280 @default.
• W2565767544 cites W2092112088 @default.
• W2565767544 cites W2096114963 @default.
• W2565767544 cites W2104941760 @default.
• W2565767544 cites W2106933177 @default.
• W2565767544 cites W2107277218 @default.
• W2565767544 cites W2114754360 @default.
• W2565767544 cites W2116392060 @default.
• W2565767544 cites W2116424197 @default.
• W2565767544 cites W2127184242 @default.
• W2565767544 cites W2128867957 @default.
• W2565767544 cites W2130574722 @default.
• W2565767544 cites W2132312679 @default.
• W2565767544 cites W2137360601 @default.
• W2565767544 cites W2138638319 @default.
• W2565767544 cites W2138794351 @default.
• W2565767544 cites W2139234903 @default.
• W2565767544 cites W2140215777 @default.
• W2565767544 cites W2158635554 @default.
• W2565767544 cites W2170748292 @default.
• W2565767544 doi "https://doi.org/10.1002/jbm.a.35977" @default.
• W2565767544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27977899" @default.
• W2565767544 hasPublicationYear "2017" @default.
• W2565767544 type Work @default.
• W2565767544 sameAs 2565767544 @default.
• W2565767544 citedByCount "6" @default.
• W2565767544 countsByYear W25657675442017 @default.
• W2565767544 countsByYear W25657675442018 @default.
• W2565767544 countsByYear W25657675442020 @default.
• W2565767544 countsByYear W25657675442022 @default.
• W2565767544 crossrefType "journal-article" @default.
• W2565767544 hasAuthorship W2565767544A5004333023 @default.
• W2565767544 hasAuthorship W2565767544A5010308877 @default.
• W2565767544 hasAuthorship W2565767544A5028320463 @default.
• W2565767544 hasAuthorship W2565767544A5029930261 @default.
• W2565767544 hasAuthorship W2565767544A5035541028 @default.
• W2565767544 hasAuthorship W2565767544A5044198759 @default.
• W2565767544 hasAuthorship W2565767544A5058240973 @default.
• W2565767544 hasAuthorship W2565767544A5062735829 @default.
• W2565767544 hasAuthorship W2565767544A5066291847 @default.
• W2565767544 hasConcept C104317684 @default.
• W2565767544 hasConcept C126322002 @default.
• W2565767544 hasConcept C148738053 @default.
• W2565767544 hasConcept C153911025 @default.
• W2565767544 hasConcept C192562407 @default.
• W2565767544 hasConcept C207200792 @default.
• W2565767544 hasConcept C2778532138 @default.
• W2565767544 hasConcept C3018686881 @default.
• W2565767544 hasConcept C36036425 @default.
• W2565767544 hasConcept C500558357 @default.
• W2565767544 hasConcept C54355233 @default.

• next