Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565778871> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2565778871 abstract "Background: Ribonucleotide reductase subunit M2 (RRM2) has been frequently observed to be aberrantly overexpressed in various tumors. RRM2 is a key enzyme, and essential regulator of balanced deoxyribonucleotides (dNTPs). It is critical for DNA replication and repair, and hence cell survival. In addition to DNA synthesis, it has been reported to modulate cellular invasiveness. However, the mechanisms through which RRM2 affects the invasive phenotype have not been elucidated. Methods: We evaluated the expression of RRM2 protein in metastatic (n = 40) and non-metastatic (n = 40) head and neck squamous cell carcinoma (HNSCC) tissue samples using immunohistochemistry (IHC). We identified varying degrees of RRM2 expression levels in HNSCC and NSCLC cell lines. We also generated RRM2 overexpressing stable cell lines; Tu686 (HNSCC) and A549 non-small cell lung carcinoma (NSCLC). In addition, we knocked down RRM2 and Twist 1 expression by siRNA technology. Results: Our results showed that RRM2 expression was significantly correlated with lymph node metastasis in HNSCC (p value Conclusions: Our study demonstrated that RRM2 substantially promoted cell invasion by stabilizing Twist 1 and suppressing E-Cadherin. Thus, an elevated RRM2 may serve as a potential biomarker for metastasis of HNSCC and NSCLC. Targeting RRM2 and its downstream signaling intermediaries may represent a rational approach for developing novel anticancer therapeutics. We are in the process of conducting an animal study to validate the strategy of silencing of RRM2 by using RRM2-siRNA nanoparticle to inhibit metastasis. (This work is supported by grants from NIH U01CA151802, P50CA128613). Citation Format: Mohammad Aminur Rahman, A.R.M. Ruhul Amin, Jun Zhang, Sreenivas Nannapaneni, Nabil F. Saba, Zhuo Georgia Chen, Dong M. Shin. Targeting RRM2 by siRNA inhibits cellular invasion and represents a rational approach for inhibition of metastasis of head and neck and lung cancers. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1428. doi:10.1158/1538-7445.AM2015-1428" @default.
- W2565778871 created "2017-01-06" @default.
- W2565778871 creator A5003855325 @default.
- W2565778871 creator A5010399375 @default.
- W2565778871 creator A5027632857 @default.
- W2565778871 creator A5036672833 @default.
- W2565778871 creator A5036760441 @default.
- W2565778871 creator A5071672663 @default.
- W2565778871 creator A5088965012 @default.
- W2565778871 date "2015-08-01" @default.
- W2565778871 modified "2023-09-26" @default.
- W2565778871 title "Abstract 1428: Targeting RRM2 by siRNA inhibits cellular invasion and represents a rational approach for inhibition of metastasis of head and neck and lung cancers" @default.
- W2565778871 doi "https://doi.org/10.1158/1538-7445.am2015-1428" @default.
- W2565778871 hasPublicationYear "2015" @default.
- W2565778871 type Work @default.
- W2565778871 sameAs 2565778871 @default.
- W2565778871 citedByCount "0" @default.
- W2565778871 crossrefType "proceedings-article" @default.
- W2565778871 hasAuthorship W2565778871A5003855325 @default.
- W2565778871 hasAuthorship W2565778871A5010399375 @default.
- W2565778871 hasAuthorship W2565778871A5027632857 @default.
- W2565778871 hasAuthorship W2565778871A5036672833 @default.
- W2565778871 hasAuthorship W2565778871A5036760441 @default.
- W2565778871 hasAuthorship W2565778871A5071672663 @default.
- W2565778871 hasAuthorship W2565778871A5088965012 @default.
- W2565778871 hasConcept C104317684 @default.
- W2565778871 hasConcept C119056186 @default.
- W2565778871 hasConcept C121608353 @default.
- W2565778871 hasConcept C126322002 @default.
- W2565778871 hasConcept C22615655 @default.
- W2565778871 hasConcept C2776530083 @default.
- W2565778871 hasConcept C2776833033 @default.
- W2565778871 hasConcept C2779013556 @default.
- W2565778871 hasConcept C502942594 @default.
- W2565778871 hasConcept C54009773 @default.
- W2565778871 hasConcept C54355233 @default.
- W2565778871 hasConcept C55493867 @default.
- W2565778871 hasConcept C71924100 @default.
- W2565778871 hasConcept C81885089 @default.
- W2565778871 hasConcept C86803240 @default.
- W2565778871 hasConceptScore W2565778871C104317684 @default.
- W2565778871 hasConceptScore W2565778871C119056186 @default.
- W2565778871 hasConceptScore W2565778871C121608353 @default.
- W2565778871 hasConceptScore W2565778871C126322002 @default.
- W2565778871 hasConceptScore W2565778871C22615655 @default.
- W2565778871 hasConceptScore W2565778871C2776530083 @default.
- W2565778871 hasConceptScore W2565778871C2776833033 @default.
- W2565778871 hasConceptScore W2565778871C2779013556 @default.
- W2565778871 hasConceptScore W2565778871C502942594 @default.
- W2565778871 hasConceptScore W2565778871C54009773 @default.
- W2565778871 hasConceptScore W2565778871C54355233 @default.
- W2565778871 hasConceptScore W2565778871C55493867 @default.
- W2565778871 hasConceptScore W2565778871C71924100 @default.
- W2565778871 hasConceptScore W2565778871C81885089 @default.
- W2565778871 hasConceptScore W2565778871C86803240 @default.
- W2565778871 hasLocation W25657788711 @default.
- W2565778871 hasOpenAccess W2565778871 @default.
- W2565778871 hasPrimaryLocation W25657788711 @default.
- W2565778871 hasRelatedWork W2049309709 @default.
- W2565778871 hasRelatedWork W2168673009 @default.
- W2565778871 hasRelatedWork W2314861245 @default.
- W2565778871 hasRelatedWork W2328919150 @default.
- W2565778871 hasRelatedWork W2497026976 @default.
- W2565778871 hasRelatedWork W2768206353 @default.
- W2565778871 hasRelatedWork W2791704705 @default.
- W2565778871 hasRelatedWork W2893086662 @default.
- W2565778871 hasRelatedWork W2916763901 @default.
- W2565778871 hasRelatedWork W2937151884 @default.
- W2565778871 hasRelatedWork W2946282523 @default.
- W2565778871 hasRelatedWork W2980583921 @default.
- W2565778871 hasRelatedWork W2989970146 @default.
- W2565778871 hasRelatedWork W2991208772 @default.
- W2565778871 hasRelatedWork W2997951888 @default.
- W2565778871 hasRelatedWork W3080241033 @default.
- W2565778871 hasRelatedWork W3133425265 @default.
- W2565778871 hasRelatedWork W3138260730 @default.
- W2565778871 hasRelatedWork W3183977106 @default.
- W2565778871 hasRelatedWork W3203628783 @default.
- W2565778871 isParatext "false" @default.
- W2565778871 isRetracted "false" @default.
- W2565778871 magId "2565778871" @default.
- W2565778871 workType "article" @default.