Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565786564> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2565786564 abstract "Abstract We analysed tyrosine phosphorylation, NF-κB activation and survival in a cohort of 64 chronic lymphocytic leukemia patients. By graphing VH gene mutational status, CD38 expression and ZAP-70 expression as continuous variables, we investigated correlations between these prognostic markers and cell signaling. There was a strong correlation between CD38 expression and basal levels of tyrosine phosphorylation (r2 = 0.68). VH gene mutational status and ZAP-70 expression correlated with the induction of tyrosine phosphorylation by anti-IgM (r2 = 0.31 and 0.46 respectively). These findings suggest that tyrosine phosphorylation integrates these three prognostic phenotypes. In the context of NF-κB signaling, the percentage change in tyrosine phosphorylation (post anti-IgM) and ZAP-70 expression correlated with NF-κB activation (r2 = 0.2 and 0.19 respectively) and the ability to activate NF-κB was strongly correlated with cell survival (r2 = 0.67). The therapeutic rationale for the inhibition of NF-κB was strengthened by our observations that the NF-κB inhibitor, BAY 11–7082, caused a concentration-dependent increase in apoptosis in CLL samples. Taken together, our data suggest that CD38 is a surrogate marker of basal cellular activation in CLL that is independent of the B-cell receptor. Furthermore, ZAP-70 expression is the most important predictor of tyrosine phosphorylation, downstream NF-κB activation and CLL cell survival following B-cell receptor cross-linking. These findings provide a mechanism-based rationale for the poor prognosis of CD38+ and ZAP-70+ CLL patients." @default.
- W2565786564 created "2017-01-06" @default.
- W2565786564 creator A5039023166 @default.
- W2565786564 creator A5041383023 @default.
- W2565786564 creator A5050134999 @default.
- W2565786564 creator A5053124814 @default.
- W2565786564 creator A5054060709 @default.
- W2565786564 creator A5085344925 @default.
- W2565786564 date "2005-11-16" @default.
- W2565786564 modified "2023-09-28" @default.
- W2565786564 title "ZAP-70 Expression Is More Predictive Than VH Gene Mutational Status of BCR-Mediated Tyrosine Phosphorylation, NF-κB Activation and CLL Cell Survival." @default.
- W2565786564 doi "https://doi.org/10.1182/blood.v106.11.2942.2942" @default.
- W2565786564 hasPublicationYear "2005" @default.
- W2565786564 type Work @default.
- W2565786564 sameAs 2565786564 @default.
- W2565786564 citedByCount "0" @default.
- W2565786564 crossrefType "journal-article" @default.
- W2565786564 hasAuthorship W2565786564A5039023166 @default.
- W2565786564 hasAuthorship W2565786564A5041383023 @default.
- W2565786564 hasAuthorship W2565786564A5050134999 @default.
- W2565786564 hasAuthorship W2565786564A5053124814 @default.
- W2565786564 hasAuthorship W2565786564A5054060709 @default.
- W2565786564 hasAuthorship W2565786564A5085344925 @default.
- W2565786564 hasConcept C10205521 @default.
- W2565786564 hasConcept C11960822 @default.
- W2565786564 hasConcept C157695867 @default.
- W2565786564 hasConcept C159654299 @default.
- W2565786564 hasConcept C159912055 @default.
- W2565786564 hasConcept C170493617 @default.
- W2565786564 hasConcept C175818844 @default.
- W2565786564 hasConcept C203014093 @default.
- W2565786564 hasConcept C2776165026 @default.
- W2565786564 hasConcept C2777553839 @default.
- W2565786564 hasConcept C2777938653 @default.
- W2565786564 hasConcept C2778453870 @default.
- W2565786564 hasConcept C2778461978 @default.
- W2565786564 hasConcept C28328180 @default.
- W2565786564 hasConcept C35174551 @default.
- W2565786564 hasConcept C42362537 @default.
- W2565786564 hasConcept C43907098 @default.
- W2565786564 hasConcept C502942594 @default.
- W2565786564 hasConcept C54355233 @default.
- W2565786564 hasConcept C55493867 @default.
- W2565786564 hasConcept C62478195 @default.
- W2565786564 hasConcept C86803240 @default.
- W2565786564 hasConcept C95444343 @default.
- W2565786564 hasConceptScore W2565786564C10205521 @default.
- W2565786564 hasConceptScore W2565786564C11960822 @default.
- W2565786564 hasConceptScore W2565786564C157695867 @default.
- W2565786564 hasConceptScore W2565786564C159654299 @default.
- W2565786564 hasConceptScore W2565786564C159912055 @default.
- W2565786564 hasConceptScore W2565786564C170493617 @default.
- W2565786564 hasConceptScore W2565786564C175818844 @default.
- W2565786564 hasConceptScore W2565786564C203014093 @default.
- W2565786564 hasConceptScore W2565786564C2776165026 @default.
- W2565786564 hasConceptScore W2565786564C2777553839 @default.
- W2565786564 hasConceptScore W2565786564C2777938653 @default.
- W2565786564 hasConceptScore W2565786564C2778453870 @default.
- W2565786564 hasConceptScore W2565786564C2778461978 @default.
- W2565786564 hasConceptScore W2565786564C28328180 @default.
- W2565786564 hasConceptScore W2565786564C35174551 @default.
- W2565786564 hasConceptScore W2565786564C42362537 @default.
- W2565786564 hasConceptScore W2565786564C43907098 @default.
- W2565786564 hasConceptScore W2565786564C502942594 @default.
- W2565786564 hasConceptScore W2565786564C54355233 @default.
- W2565786564 hasConceptScore W2565786564C55493867 @default.
- W2565786564 hasConceptScore W2565786564C62478195 @default.
- W2565786564 hasConceptScore W2565786564C86803240 @default.
- W2565786564 hasConceptScore W2565786564C95444343 @default.
- W2565786564 hasLocation W25657865641 @default.
- W2565786564 hasOpenAccess W2565786564 @default.
- W2565786564 hasPrimaryLocation W25657865641 @default.
- W2565786564 hasRelatedWork W1552779466 @default.
- W2565786564 hasRelatedWork W2032189192 @default.
- W2565786564 hasRelatedWork W2033315156 @default.
- W2565786564 hasRelatedWork W2134916100 @default.
- W2565786564 hasRelatedWork W2135781988 @default.
- W2565786564 hasRelatedWork W2565786564 @default.
- W2565786564 hasRelatedWork W2587928048 @default.
- W2565786564 hasRelatedWork W2980054351 @default.
- W2565786564 hasRelatedWork W4242103831 @default.
- W2565786564 hasRelatedWork W96390394 @default.
- W2565786564 isParatext "false" @default.
- W2565786564 isRetracted "false" @default.
- W2565786564 magId "2565786564" @default.
- W2565786564 workType "article" @default.