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- W2565786983 abstract "Sterile neuroinflammation is essential for the proper brain development and tissue repair. However, uncontrolled neuroinflammation plays a major role in the pathogenesis of various disease processes. The endogenous intracellular molecules so called damage-associated molecular patterns or alarmins or damage signals that are released by activated or necrotic cells are thought to play a crucial role in initiating an immune response. Sterile inflammatory response that occurs in Alzheimer’s disease (AD), Parkinson’s disease (PD), stroke, hemorrhage, epilepsy, or traumatic brain injury (TBI) creates a vicious cycle of unrestrained inflammation, driving progressive neurodegeneration. Neuroinflammation is a key mechanism in the progression (e.g., AD and PD) or secondary injury development (e.g., stroke, hemorrhage, stress, and TBI) of multiple brain conditions. Hence, it provides an opportunity for the therapeutic intervention to prevent progressive tissue damage and loss of function. The key for developing anti-neuroinflammatory treatment is to minimize the detrimental and neurotoxic effects of inflammation while promoting the beneficial and neurotropic effects, thereby creating ideal conditions for regeneration and repair. This review outlines how inflammation is involved in the pathogenesis of major nonpathogenic neuroinflammatory conditions and discusses the complex response of glial cells to damage signals. In addition, emerging experimental anti-neuroinflammatory drug treatment strategies are discussed." @default.
- W2565786983 created "2017-01-06" @default.
- W2565786983 creator A5015993316 @default.
- W2565786983 creator A5022149512 @default.
- W2565786983 date "2017-01-01" @default.
- W2565786983 modified "2023-10-15" @default.
- W2565786983 title "Sterile Neuroinflammation and Strategies for Therapeutic Intervention" @default.
- W2565786983 cites W1224852380 @default.
- W2565786983 cites W1481432786 @default.
- W2565786983 cites W1498875382 @default.
- W2565786983 cites W1502625668 @default.
- W2565786983 cites W1510059371 @default.
- W2565786983 cites W1524579332 @default.
- W2565786983 cites W1524705340 @default.
- W2565786983 cites W1541257670 @default.
- W2565786983 cites W1548992350 @default.
- W2565786983 cites W1549985638 @default.
- W2565786983 cites W1552106782 @default.
- W2565786983 cites W1563590122 @default.
- W2565786983 cites W1573846225 @default.
- W2565786983 cites W1589966695 @default.
- W2565786983 cites W1589993557 @default.
- W2565786983 cites W1614633287 @default.
- W2565786983 cites W1620345881 @default.
- W2565786983 cites W1656741156 @default.
- W2565786983 cites W1729585270 @default.
- W2565786983 cites W1752819622 @default.
- W2565786983 cites W1834139870 @default.
- W2565786983 cites W1892746652 @default.
- W2565786983 cites W1912706849 @default.
- W2565786983 cites W1914440735 @default.
- W2565786983 cites W1919476441 @default.
- W2565786983 cites W1923994946 @default.
- W2565786983 cites W1929515229 @default.
- W2565786983 cites W1934778253 @default.
- W2565786983 cites W1936565989 @default.
- W2565786983 cites W1941035309 @default.
- W2565786983 cites W1965764984 @default.
- W2565786983 cites W1966634013 @default.
- W2565786983 cites W1967081185 @default.
- W2565786983 cites W1967434989 @default.
- W2565786983 cites W1967912747 @default.
- W2565786983 cites W1968057097 @default.
- W2565786983 cites W1968420305 @default.
- W2565786983 cites W1969452337 @default.
- W2565786983 cites W1970469252 @default.
- W2565786983 cites W1971346646 @default.
- W2565786983 cites W1973553804 @default.
- W2565786983 cites W1973784760 @default.
- W2565786983 cites W1976445933 @default.
- W2565786983 cites W1977291679 @default.
- W2565786983 cites W1977347871 @default.
- W2565786983 cites W1978525572 @default.
- W2565786983 cites W1978872562 @default.
- W2565786983 cites W1983419107 @default.
- W2565786983 cites W1984008481 @default.
- W2565786983 cites W1984158584 @default.
- W2565786983 cites W1984349693 @default.
- W2565786983 cites W1986611577 @default.
- W2565786983 cites W1986977913 @default.
- W2565786983 cites W1988178045 @default.
- W2565786983 cites W1988412016 @default.
- W2565786983 cites W1989591516 @default.
- W2565786983 cites W1994190235 @default.
- W2565786983 cites W1996838741 @default.
- W2565786983 cites W1997908175 @default.
- W2565786983 cites W1998981667 @default.
- W2565786983 cites W2003955184 @default.
- W2565786983 cites W2006610133 @default.
- W2565786983 cites W2007855994 @default.
- W2565786983 cites W2008889685 @default.
- W2565786983 cites W2009102898 @default.
- W2565786983 cites W2010247798 @default.
- W2565786983 cites W2010915352 @default.
- W2565786983 cites W2011850283 @default.
- W2565786983 cites W2012032118 @default.
- W2565786983 cites W2012468274 @default.
- W2565786983 cites W2015541518 @default.
- W2565786983 cites W2016436821 @default.
- W2565786983 cites W2016575029 @default.
- W2565786983 cites W2017894103 @default.
- W2565786983 cites W2018460125 @default.
- W2565786983 cites W2020189206 @default.
- W2565786983 cites W2022981588 @default.
- W2565786983 cites W2023517019 @default.
- W2565786983 cites W2027224845 @default.
- W2565786983 cites W2027654721 @default.
- W2565786983 cites W2029589758 @default.
- W2565786983 cites W2031786917 @default.
- W2565786983 cites W2033242795 @default.
- W2565786983 cites W2034210170 @default.
- W2565786983 cites W2034430748 @default.
- W2565786983 cites W2034607987 @default.
- W2565786983 cites W2035221144 @default.
- W2565786983 cites W2035299031 @default.
- W2565786983 cites W2037114292 @default.
- W2565786983 cites W2040892689 @default.
- W2565786983 cites W2042288276 @default.