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- W2565789084 abstract "Infection rates in revision (second and subsequent) major joint arthroplasty continues to be a significant issue with rates 2-3 times those of primary procedures. The effect of antibiotic and antiseptic prophylaxis on outcomes for this type of surgery has not been adequately reviewed.A systematic search of the main databases for randomized controlled trials (RCTs) evaluating antibiotics and antiseptics was conducted to evaluate the predetermined endpoints of infection.There were five (5) RCTs identified that examined the effects of antibiotic and antiseptic prophylaxis on infections after revision total hip arthroplasty [THA] (total of 304 participants) and total knee arthroplasty [TKA] (total of 206 participants). For TKA, preoperative systemic intravenous (IV) antibiotic prophylaxis plus antibiotic cement may be effective in reducing the incidence of infection in revision TKA at 8+ years. These results however should be interpreted with caution due to the significant biases. For revision THA, there is no RCT evidence that antibiotics/antiseptics have any effect on the infection rate.There is a lack of high quality data demonstrating an effect of antibiotics or antiseptics on infection rates in revision THA/TKA. Considering the rate of infections in revisions is 2-3X that of primary procedures and; there is a consensus recommendation to use similar antibiotic and antiseptic regimens in both primary and revision procedures, there is a need for high quality studies in revision THA/TKA." @default.
- W2565789084 created "2017-01-06" @default.
- W2565789084 creator A5020321347 @default.
- W2565789084 creator A5040198581 @default.
- W2565789084 creator A5066705186 @default.
- W2565789084 date "2016-12-01" @default.
- W2565789084 modified "2023-10-08" @default.
- W2565789084 title "Antibiotics and antiseptics for preventing infection in people receiving revision total hip and knee prostheses: a systematic review of randomized controlled trials" @default.
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- W2565789084 doi "https://doi.org/10.1186/s12879-016-2063-4" @default.
- W2565789084 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5153681" @default.
- W2565789084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27955626" @default.
- W2565789084 hasPublicationYear "2016" @default.
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