FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2565805966> ?p ?o ?g. }

• W2565805966 abstract "Introduction: Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality in the world. As this disease is progressive in its nature, patients suffer a gradual decline in their quality of life due to a progressive deterioration in lung function. Although there are treatments available to alleviate COPD symptoms, there is no pharmacological treatment that stops the decline in lung function within the lungs of COPD patients. Literature has suggested that angiotensin-converting enzyme inhibitors (ACEi) could potentially reverse lung decline but there is limited research into angiotensin-converting enzyme (ACE) in COPD lung. The work in this thesis investigated lung ACE as well as other enzymes associated with the renin-angiotensin system (RAS) within the lungs of COPD patients. Methods: Lung samples were taken from subjects undergoing surgery. These subjects were classified according to their lung function into groups of COPD (n=36) or nonCOPD (n=34). The lung samples were evaluated for the localisation, abundance and activity of enzymes that are associated with the production of RAS peptides: ACE, chymase, renin and ACE-2. This was by immunohistochemistry and enzymatic assays. The number of positive cells/vessels and the activity of these enzymes were measured in COPD lung and compared to subjects without COPD. The effects of ACEi prescribed to these subjects as well as their smoking status on lung enzyme expression and activity were also investigated. Results: ACE activity was significantly lower in the lungs of COPD subjects compared to subjects without COPD. For the first time, ACE-2 staining was observed in macrophages from lung tissue as well as monocyte-derived macrophages (Mdm) and this human ACE-2 protein seemed catalytically active. ACE-2 activity and expression seemed to be higher in COPD and also in smokers compared to controls however this was not significant. Conclusions: The activity of the RAS is overlooked as a potential risk factor for COPD. The work in this thesis has identified that the RAS enzyme ACE is linked with COPD and could be a target for pharmacological treatment of lung decline observed in COPD in the future. Another enzyme of the RAS, ACE-2 is localised to the lung macrophage, which is a cell associated with the inflammatory response. This finding could spark research into the function of ACE-2 in the macrophage and ACE-2 expression modification may be beneficial for inflammatory disease such as COPD in the future." @default.
• W2565805966 created "2017-01-06" @default.
• W2565805966 creator A5088380555 @default.
• W2565805966 date "2016-03-01" @default.
• W2565805966 modified "2023-09-24" @default.
• W2565805966 title "The renin-angiotensin system enzymes in chronic obstructive pulmonary disease" @default.
• W2565805966 hasPublicationYear "2016" @default.
• W2565805966 type Work @default.
• W2565805966 sameAs 2565805966 @default.
• W2565805966 citedByCount "0" @default.
• W2565805966 crossrefType "dissertation" @default.
• W2565805966 hasAuthorship W2565805966A5088380555 @default.
• W2565805966 hasConcept C126322002 @default.
• W2565805966 hasConcept C134018914 @default.
• W2565805966 hasConcept C142724271 @default.
• W2565805966 hasConcept C164705383 @default.
• W2565805966 hasConcept C198710026 @default.
• W2565805966 hasConcept C27016395 @default.
• W2565805966 hasConcept C2776780178 @default.
• W2565805966 hasConcept C2777104659 @default.
• W2565805966 hasConcept C2777714996 @default.
• W2565805966 hasConcept C71924100 @default.
• W2565805966 hasConcept C84393581 @default.
• W2565805966 hasConceptScore W2565805966C126322002 @default.
• W2565805966 hasConceptScore W2565805966C134018914 @default.
• W2565805966 hasConceptScore W2565805966C142724271 @default.
• W2565805966 hasConceptScore W2565805966C164705383 @default.
• W2565805966 hasConceptScore W2565805966C198710026 @default.
• W2565805966 hasConceptScore W2565805966C27016395 @default.
• W2565805966 hasConceptScore W2565805966C2776780178 @default.
• W2565805966 hasConceptScore W2565805966C2777104659 @default.
• W2565805966 hasConceptScore W2565805966C2777714996 @default.
• W2565805966 hasConceptScore W2565805966C71924100 @default.
• W2565805966 hasConceptScore W2565805966C84393581 @default.
• W2565805966 hasLocation W25658059661 @default.
• W2565805966 hasOpenAccess W2565805966 @default.
• W2565805966 hasPrimaryLocation W25658059661 @default.
• W2565805966 hasRelatedWork W120533588 @default.
• W2565805966 hasRelatedWork W1573345953 @default.
• W2565805966 hasRelatedWork W1808580625 @default.
• W2565805966 hasRelatedWork W2270488225 @default.
• W2565805966 hasRelatedWork W2284026709 @default.
• W2565805966 hasRelatedWork W2328344080 @default.
• W2565805966 hasRelatedWork W2359045641 @default.
• W2565805966 hasRelatedWork W2360861626 @default.
• W2565805966 hasRelatedWork W2400259636 @default.
• W2565805966 hasRelatedWork W2414566874 @default.
• W2565805966 hasRelatedWork W2613293232 @default.
• W2565805966 hasRelatedWork W2897778024 @default.
• W2565805966 hasRelatedWork W2953931406 @default.
• W2565805966 hasRelatedWork W2990418905 @default.
• W2565805966 hasRelatedWork W3007399857 @default.
• W2565805966 hasRelatedWork W3123045749 @default.
• W2565805966 hasRelatedWork W3155657194 @default.
• W2565805966 hasRelatedWork W3197546543 @default.
• W2565805966 hasRelatedWork W3206854744 @default.
• W2565805966 hasRelatedWork W56779886 @default.
• W2565805966 isParatext "false" @default.
• W2565805966 isRetracted "false" @default.
• W2565805966 magId "2565805966" @default.
• W2565805966 workType "dissertation" @default.