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- W2565880583 abstract "Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer-related death all over the world. This disease is difficult to treat and patients have an overall 5-year survival rate of less than 5%. Although two drugs, gemcitabine (GEM) and 5-fluorouracil (5-FU) have been shown to improve the survival rate of patients systematically, they do not increase general survival to a clinically acceptable degree. Lack of ideal clinical response of pancreatic cancer patients to chemotherapy is likely to be due to intrinsic and acquired chemoresistance of tumor cells. Various mechanisms of drug resistance have been investigated in pancreatic cancer, including genetic and epigenetic changes in particular genes or signaling pathways. In addition, evidence suggests that microRNAs (miRNAs) play significant roles as key regulators of gene expression in many cellular processes, including drug resistance. Understanding underlying genes and mechanisms of drug resistance in pancreatic cancer is critical to develop new effective treatments for this deadly disease. This review illustrates the genes and miRNAs involved in resistance to gemcitabine in pancreatic cancer." @default.
- W2565880583 created "2017-01-06" @default.
- W2565880583 creator A5027563455 @default.
- W2565880583 creator A5055158419 @default.
- W2565880583 creator A5062211181 @default.
- W2565880583 date "2017-03-01" @default.
- W2565880583 modified "2023-09-24" @default.
- W2565880583 title "Molecular alterations contributing to pancreatic cancer chemoresistance" @default.
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