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- W2565884202 abstract "Abstract A continual multicomponent model of growth of a low-invasive tumor is a developed subject to the angiogenesis and single bevacizumab therapy. The model takes into account the differences in permeabilities of the pre-existent vasculature and the vasculature formed as the result of angiogenesis. The dependence of the antitumor therapy efficacy on the bev dosage is studied. It is found out that in the case of successful treatment the tumor may pass from a compact convective growth to diffuse intergrowth followed by significant reduction in the growth rate and the number of active tumor cells. It is shown that the bev dosage sufficient for successful treatment is significantly less than it is commonly accepted in clinical practice. A scheme of bev prescription allowing a significant reduction of both the costs of therapy and its negative effects while maintaining antitumor efficacy is proposed." @default.
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- W2565884202 date "2015-01-01" @default.
- W2565884202 modified "2023-09-26" @default.
- W2565884202 title "The study of antitumor efficacy of bevacizumab antiangiogenic therapy using a mathematical model" @default.
- W2565884202 doi "https://doi.org/10.1515/rnam-2015-0026" @default.
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