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• W2565929897 abstract "Abstract In the higher eukaryotic nucleolus, fibrillar centers (FCs), the dense fibrillar components (DFCs), and the granular components (GCs) are functional domains structurally relatively well‐defined by electron microscopy (EM). However, ultrastructural alterations in FC, DFC, and GC during the cell cycle and their associated cellular functions are still largely unclear. Based on synchronized HeLa cells, we followed the structural dynamics of nucleolus during cell cycle by EM. We found that nucleolus structure shifted from tripartite to bipartite organization and FC/DFCs were reorganized in S phase with three distinct stages: (1) In early‐S phase, FC/DFC structures were disassembled. (2) In mid‐S phase, a transition from FC/DFC disruption to restoration occurred. As FC/DFC structures were completely disassembled, nucleoli became structurally homogenous. (3) In late‐S phase, the number of small FC/DFCs increased and subsequently large FC/DFCs were constructed. Our data demonstrated that nucleolar FC/DFCs in interphase are presented in two different forms or states due to disassembly and reassembly. FC/DFCs in G1 are nucleolar structures constructed concomitantly with the establishment of nucleoli derived from the nucleolar organizer region (NOR). FC/DFCs in G2 are nucleolar components reconstituted after the global reassembly in mid‐S phase. Dynamic nucleolus structures revealed in this study may serve as ultrastructural characteristics to reflect distinct stages of the cell cycle. By providing evidence for the temporal and spatial regulation of nucleolus, our findings contribute to the coupling of nucleolus structures to cell cycle dependent functions." @default.
• W2565929897 created "2017-01-06" @default.
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• W2565929897 date "2017-01-24" @default.
• W2565929897 modified "2023-10-16" @default.
• W2565929897 title "Disruption and restoration of nucleolar FC and DFC during S phase in HeLa cells" @default.
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• W2565929897 doi "https://doi.org/10.1002/cbin.10719" @default.
• W2565929897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28032386" @default.
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