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- W2565971128 abstract "For the past three-quarters of a century, detecting a monoclonal immunoglobulin (also called M-protein) by serum protein electrophoresis (SPEP)2 and immunofixation (IFE) has been evidence of a monoclonal gammopathy. However, deployment of Food and Drug Administration (FDA)-approved therapeutic monoclonal antibodies (t-mAbs) for a wide variety of inflammatory and neoplastic conditions necessitates a caveat when small quantities of M-proteins are found.Recognition, measurement, and characterization of M-proteins along with the serum free light chain ratio are crucial laboratory tests for evaluating patients suspected of harboring a monoclonal gammopathy. The complex array of infirmities encompassing monoclonal gammopathies ranges from the premalignant monoclonal gammopathy of undetermined significance (MGUS) to the unrelenting malignancy, multiple myeloma (MM). Because all cases of MM evolve from MGUS, even relatively small M-proteins need to be followed, although their size, isotype, and free light chain ratio along with clinical findings determine the frequency and extent of monitoring required.As Mills and Murray (1) point out in their timely review, not realizing that small M-protein spikes on an initial SPEP screen can be seen in patients receiving t-mAbs may launch a costly series of laboratory tests and radiologic examinations, as well as triggering needless concern for patients during evaluation of a nonexistent MGUS. Fortunately, the dose of most t-mAbs is too …" @default.
- W2565971128 created "2017-01-06" @default.
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- W2565971128 date "2016-11-21" @default.
- W2565971128 modified "2023-09-22" @default.
- W2565971128 title "Therapeutic Complications: A Caveat for M-Protein Detection" @default.
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- W2565971128 doi "https://doi.org/10.1373/jalm.2016.022319" @default.
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