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- W2565997602 abstract "Abstract Genetic diversity has underpinned the survival and expansion of human populations against a long history of varied microbial challenges, but may limit the universal immunogenicity of current vaccines against particular pathogens. Reduced or non-responsiveness is a barrier to total pathogen eradication for established vaccines, and remains the key impediment to licensure for a number of investigational vaccines. Genetic association studies have identified some determinants of vaccine immunogenicity, many of which act at single molecular interactions within complex pathways and networks. To date these immune modifying polymorphisms explain only a fraction of the known variation in vaccine responses and the most striking aspect of individualized immunity, immunodominance, remains a central issue in new vaccine design. Vaccine personalization is likely to require not only a systems biology approach to understand broad vaccine response phenotypes, but also an understanding that the specificity of antigen recognition unique to every vaccinee and restricted by their human leukocyte antigen (HLA) genotype, determines the unique CD4 and CD8 T cell and natural killer (NK) cell repertoires available for vaccine induction. This chapter discusses the role of HLA and non-HLA loci, and pathogen-specific adaptations relevant to vaccines and explores ways these could be exploited in vaccine design and personalization." @default.
- W2565997602 created "2017-01-06" @default.
- W2565997602 creator A5070165631 @default.
- W2565997602 creator A5080161419 @default.
- W2565997602 creator A5083545834 @default.
- W2565997602 date "2017-01-01" @default.
- W2565997602 modified "2023-09-26" @default.
- W2565997602 title "Immunogenetics and Vaccination" @default.
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- W2565997602 doi "https://doi.org/10.1016/b978-0-12-802302-0.00005-4" @default.