SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2566030841> ?p ?o ?g. }

Showing items 1 to 100 of ±120 with 100 items per page.

W2566030841 endingPage "1039" @default.
W2566030841 startingPage "1031" @default.
W2566030841 abstract "BACKGROUND Hematopoietic stem cell mobilization and leukapheresis in adult patients with β‐thalassemia have recently been optimized in the context of clinical trials for obtaining hematopoietic stem cells for thalassemia gene therapy. In some patients, however, the yield of cluster of differentiation 34‐positive (CD34+) cells was poor despite successful mobilization, and a modification of apheresis settings was mandatory for harvest rescue. STUDY DESIGN AND METHODS Data were analyzed from 20 adult patients with β‐thalassemia who were enrolled in a clinical trial of optimizing mobilization strategies for stem cell gene therapy. The aim of this post‐hoc analysis was to assess how certain hematological and/or clinical parameters may correlate with low collection efficiency in the presence of adequate numbers of circulating stem cells after pharmacological mobilization and standard leukapheresis procedures. RESULTS Among 19 patients who achieved optimal mobilization with Plerixafor, four who underwent splenectomy demonstrated disproportionately poor CD34+ cell harvests, as determined by their circulating CD34+ cell counts after mobilization. All four patients who underwent splenectomy presented at baseline and before first apheresis with lymphocytosis resulting in lymphocyte/neutrophil ratios well above 1 and marked reticulocytosis compared with patients who achieved optimal mobilization/CD34+ cell harvest. Such unexpected expansion of specific cell populations disrupted the normal cell layer separation and necessitated modification of the apheresis settings to rescue the harvests. CONCLUSIONS By close examination of certain hematological and/or clinical parameters before leukapheresis, patients who, despite adequate mobilization, are at risk for poor CD34+ cell harvests may be identified, and harvest failure can be prevented by adjusting the apheresis settings." @default.
W2566030841 created "2017-01-06" @default.
W2566030841 creator A5002560472 @default.
W2566030841 creator A5018345688 @default.
W2566030841 creator A5033587004 @default.
W2566030841 creator A5061396376 @default.
W2566030841 creator A5063011644 @default.
W2566030841 creator A5085228898 @default.
W2566030841 creator A5086793596 @default.
W2566030841 creator A5089992014 @default.
W2566030841 date "2016-12-17" @default.
W2566030841 modified "2023-09-27" @default.
W2566030841 title "Poor stem cell harvest may not always be related to poor mobilization: lessons gained from a mobilization study in patients with β-thalassemia major" @default.
W2566030841 cites W120762819 @default.
W2566030841 cites W1510760051 @default.
W2566030841 cites W1526986700 @default.
W2566030841 cites W1532162953 @default.
W2566030841 cites W1604146979 @default.
W2566030841 cites W1943290640 @default.
W2566030841 cites W1987266525 @default.
W2566030841 cites W2006578824 @default.
W2566030841 cites W2007891374 @default.
W2566030841 cites W2010365172 @default.
W2566030841 cites W2011361159 @default.
W2566030841 cites W2017046957 @default.
W2566030841 cites W2035386580 @default.
W2566030841 cites W2043331044 @default.
W2566030841 cites W2067032417 @default.
W2566030841 cites W2122923012 @default.
W2566030841 cites W2148137098 @default.
W2566030841 cites W2153994010 @default.
W2566030841 cites W2164576594 @default.
W2566030841 cites W2342146763 @default.
W2566030841 cites W2343013666 @default.
W2566030841 cites W37452764 @default.
W2566030841 doi "https://doi.org/10.1111/trf.13951" @default.
W2566030841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5386803" @default.
W2566030841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27987208" @default.
W2566030841 hasPublicationYear "2016" @default.
W2566030841 type Work @default.
W2566030841 sameAs 2566030841 @default.
W2566030841 citedByCount "10" @default.
W2566030841 countsByYear W25660308412018 @default.
W2566030841 countsByYear W25660308412019 @default.
W2566030841 countsByYear W25660308412020 @default.
W2566030841 countsByYear W25660308412021 @default.
W2566030841 countsByYear W25660308412022 @default.
W2566030841 countsByYear W25660308412023 @default.
W2566030841 crossrefType "journal-article" @default.
W2566030841 hasAuthorship W2566030841A5002560472 @default.
W2566030841 hasAuthorship W2566030841A5018345688 @default.
W2566030841 hasAuthorship W2566030841A5033587004 @default.
W2566030841 hasAuthorship W2566030841A5061396376 @default.
W2566030841 hasAuthorship W2566030841A5063011644 @default.
W2566030841 hasAuthorship W2566030841A5085228898 @default.
W2566030841 hasAuthorship W2566030841A5086793596 @default.
W2566030841 hasAuthorship W2566030841A5089992014 @default.
W2566030841 hasBestOaLocation W25660308412 @default.
W2566030841 hasConcept C10205521 @default.
W2566030841 hasConcept C126322002 @default.
W2566030841 hasConcept C129470790 @default.
W2566030841 hasConcept C13373296 @default.
W2566030841 hasConcept C141071460 @default.
W2566030841 hasConcept C156708679 @default.
W2566030841 hasConcept C166957645 @default.
W2566030841 hasConcept C203014093 @default.
W2566030841 hasConcept C2776738589 @default.
W2566030841 hasConcept C2777371436 @default.
W2566030841 hasConcept C2777799968 @default.
W2566030841 hasConcept C2778828106 @default.
W2566030841 hasConcept C28328180 @default.
W2566030841 hasConcept C54355233 @default.
W2566030841 hasConcept C71924100 @default.
W2566030841 hasConcept C86803240 @default.
W2566030841 hasConcept C8891405 @default.
W2566030841 hasConcept C89560881 @default.
W2566030841 hasConcept C95457728 @default.
W2566030841 hasConceptScore W2566030841C10205521 @default.
W2566030841 hasConceptScore W2566030841C126322002 @default.
W2566030841 hasConceptScore W2566030841C129470790 @default.
W2566030841 hasConceptScore W2566030841C13373296 @default.
W2566030841 hasConceptScore W2566030841C141071460 @default.
W2566030841 hasConceptScore W2566030841C156708679 @default.
W2566030841 hasConceptScore W2566030841C166957645 @default.
W2566030841 hasConceptScore W2566030841C203014093 @default.
W2566030841 hasConceptScore W2566030841C2776738589 @default.
W2566030841 hasConceptScore W2566030841C2777371436 @default.
W2566030841 hasConceptScore W2566030841C2777799968 @default.
W2566030841 hasConceptScore W2566030841C2778828106 @default.
W2566030841 hasConceptScore W2566030841C28328180 @default.
W2566030841 hasConceptScore W2566030841C54355233 @default.
W2566030841 hasConceptScore W2566030841C71924100 @default.
W2566030841 hasConceptScore W2566030841C86803240 @default.
W2566030841 hasConceptScore W2566030841C8891405 @default.
W2566030841 hasConceptScore W2566030841C89560881 @default.
W2566030841 hasConceptScore W2566030841C95457728 @default.
W2566030841 hasFunder F4320332161 @default.
W2566030841 hasIssue "4" @default.