FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2566071082> ?p ?o ?g. }

• W2566071082 endingPage "3554" @default.
• W2566071082 startingPage "3540" @default.
• W2566071082 abstract "Sequence-specific binding of proteins to DNA is essential for almost all the cellular processes like transcription, translation, replication, etc. One among the various mechanisms that has been identified so far that contributes to the specificity in protein–DNA interaction is the DNA conformational change. Electrostatic neutralization of the phosphate groups by the positively charged amino acid residues in proteins is thought to bring about such conformational changes in DNA. Here, we employ molecular dynamics simulations to examine the effect of charge on amino acids Lys113, Arg145, and Asp91 which are attached to the scissile phosphate on the conformation of DNA in EcoRI–DNA complex. The results indicate that the charge of these amino acids is essential for maintaining the local conformation of DNA in the EcoRI-bound form. Interestingly, we observe that the positively charged amino acids Lys113 and Arg145 have a long-range influence on the DNA conformation, whereas the negatively charged amino acid Asp91 has only a localized effect on the DNA conformation. The charge on the amino acids also alters the collective dynamics of EcoRI. Collectively, the results shed light on the diversity of the effect of charges on DNA conformation as well as on protein dynamics." @default.
• W2566071082 created "2017-01-06" @default.
• W2566071082 creator A5010522878 @default.
• W2566071082 creator A5027072763 @default.
• W2566071082 creator A5090007293 @default.
• W2566071082 date "2016-12-09" @default.
• W2566071082 modified "2023-10-15" @default.
• W2566071082 title "Investigating the effect of charged amino acids on DNA conformation in EcoRI–DNA complex: a molecular dynamics simulation study" @default.
• W2566071082 cites W1031578623 @default.
• W2566071082 cites W1968046716 @default.
• W2566071082 cites W1968185864 @default.
• W2566071082 cites W1975797573 @default.
• W2566071082 cites W1976499671 @default.
• W2566071082 cites W1977146894 @default.
• W2566071082 cites W1980722147 @default.
• W2566071082 cites W1986586522 @default.
• W2566071082 cites W1997459080 @default.
• W2566071082 cites W2000213161 @default.
• W2566071082 cites W2008832557 @default.
• W2566071082 cites W2010506822 @default.
• W2566071082 cites W2011234219 @default.
• W2566071082 cites W2014185588 @default.
• W2566071082 cites W2016661940 @default.
• W2566071082 cites W2017274030 @default.
• W2566071082 cites W2025774053 @default.
• W2566071082 cites W2031284125 @default.
• W2566071082 cites W2037159954 @default.
• W2566071082 cites W2038003996 @default.
• W2566071082 cites W2038532826 @default.
• W2566071082 cites W2045683699 @default.
• W2566071082 cites W2067174909 @default.
• W2566071082 cites W2071860330 @default.
• W2566071082 cites W2074718022 @default.
• W2566071082 cites W2101421856 @default.
• W2566071082 cites W2102154371 @default.
• W2566071082 cites W2117932491 @default.
• W2566071082 cites W2149142276 @default.
• W2566071082 cites W2154447604 @default.
• W2566071082 cites W2155844132 @default.
• W2566071082 cites W2161605421 @default.
• W2566071082 cites W2204959575 @default.
• W2566071082 cites W4232555805 @default.
• W2566071082 cites W4240954493 @default.
• W2566071082 cites W4254085062 @default.
• W2566071082 cites W4255916494 @default.
• W2566071082 doi "https://doi.org/10.1080/07391102.2016.1261741" @default.
• W2566071082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27935429" @default.
• W2566071082 hasPublicationYear "2016" @default.
• W2566071082 type Work @default.
• W2566071082 sameAs 2566071082 @default.
• W2566071082 citedByCount "3" @default.
• W2566071082 countsByYear W25660710822018 @default.
• W2566071082 countsByYear W25660710822023 @default.
• W2566071082 crossrefType "journal-article" @default.
• W2566071082 hasAuthorship W2566071082A5010522878 @default.
• W2566071082 hasAuthorship W2566071082A5027072763 @default.
• W2566071082 hasAuthorship W2566071082A5090007293 @default.
• W2566071082 hasConcept C104317684 @default.
• W2566071082 hasConcept C119599485 @default.
• W2566071082 hasConcept C12554922 @default.
• W2566071082 hasConcept C127413603 @default.
• W2566071082 hasConcept C128319531 @default.
• W2566071082 hasConcept C130123407 @default.
• W2566071082 hasConcept C147597530 @default.
• W2566071082 hasConcept C185592680 @default.
• W2566071082 hasConcept C2777339483 @default.
• W2566071082 hasConcept C515207424 @default.
• W2566071082 hasConcept C5179208 @default.
• W2566071082 hasConcept C552990157 @default.
• W2566071082 hasConcept C55493867 @default.
• W2566071082 hasConcept C59593255 @default.
• W2566071082 hasConcept C71240020 @default.
• W2566071082 hasConcept C73573662 @default.
• W2566071082 hasConcept C86339819 @default.
• W2566071082 hasConcept C86803240 @default.
• W2566071082 hasConcept C87716614 @default.
• W2566071082 hasConcept C94966510 @default.
• W2566071082 hasConceptScore W2566071082C104317684 @default.
• W2566071082 hasConceptScore W2566071082C119599485 @default.
• W2566071082 hasConceptScore W2566071082C12554922 @default.
• W2566071082 hasConceptScore W2566071082C127413603 @default.
• W2566071082 hasConceptScore W2566071082C128319531 @default.
• W2566071082 hasConceptScore W2566071082C130123407 @default.
• W2566071082 hasConceptScore W2566071082C147597530 @default.
• W2566071082 hasConceptScore W2566071082C185592680 @default.
• W2566071082 hasConceptScore W2566071082C2777339483 @default.
• W2566071082 hasConceptScore W2566071082C515207424 @default.
• W2566071082 hasConceptScore W2566071082C5179208 @default.
• W2566071082 hasConceptScore W2566071082C552990157 @default.
• W2566071082 hasConceptScore W2566071082C55493867 @default.
• W2566071082 hasConceptScore W2566071082C59593255 @default.
• W2566071082 hasConceptScore W2566071082C71240020 @default.
• W2566071082 hasConceptScore W2566071082C73573662 @default.
• W2566071082 hasConceptScore W2566071082C86339819 @default.
• W2566071082 hasConceptScore W2566071082C86803240 @default.
• W2566071082 hasConceptScore W2566071082C87716614 @default.
• W2566071082 hasConceptScore W2566071082C94966510 @default.
• W2566071082 hasFunder F4320320719 @default.

• next