FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2566071722> ?p ?o ?g. }

• W2566071722 endingPage "e0167908" @default.
• W2566071722 startingPage "e0167908" @default.
• W2566071722 abstract "Desminopathies caused by the mutation in the gene coding for desmin are genetically protein aggregation myopathies. Mitochondrial dysfunction is one of pathological changes in the desminopathies at the earliest stage. The molecular mechanisms of mitochondria dysfunction in desminopathies remain exclusive. VDAC1 regulates mitochondrial uptake across the outer membrane and mitochondrial outer membrane permeabilization (MOMP). Relationships between desminopathies and Voltage-dependent anion channel 1 (VDAC1) remain unclear. Here we successfully constructed the desminopathy rat model, evaluated with conventional stains, containing hematoxylin and eosin (HE), Gomori Trichrome (MGT), (PAS), red oil (ORO), NADH-TR, SDH staining and immunohistochemistry. Immunofluorescence results showed that VDAC1 was accumulated in the desmin highly stained area of muscle fibers of desminopathy patients or desminopathy rat model compared to the normal ones. Meanwhile apoptosis related proteins bax and ATF2 were involved in desminopathy patients and desminopathy rat model, but not bcl-2, bcl-xl or HK2.VDAC1 and desmin are closely relevant in the tissue splices of deminopathies patients and rats with desminopathy at protein lever. Moreover, apoptotic proteins are also involved in the desminopathies, like bax, ATF2, but not bcl-2, bcl-xl or HK2. This pathological analysis presents the correlation between VDAC1 and desmin, and apoptosis related proteins are correlated in the desminopathy. Furthermore, we provide a rat model of desminopathy for the investigation of desmin related myopathy." @default.
• W2566071722 created "2017-01-06" @default.
• W2566071722 creator A5023224774 @default.
• W2566071722 creator A5048309955 @default.
• W2566071722 creator A5048818386 @default.
• W2566071722 creator A5051900412 @default.
• W2566071722 creator A5076901473 @default.
• W2566071722 creator A5088907366 @default.
• W2566071722 date "2016-12-12" @default.
• W2566071722 modified "2023-10-01" @default.
• W2566071722 title "Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy" @default.
• W2566071722 cites W1503813864 @default.
• W2566071722 cites W1518874176 @default.
• W2566071722 cites W1605149237 @default.
• W2566071722 cites W1732186091 @default.
• W2566071722 cites W1871524663 @default.
• W2566071722 cites W1968615836 @default.
• W2566071722 cites W1969115683 @default.
• W2566071722 cites W1974341306 @default.
• W2566071722 cites W1980100638 @default.
• W2566071722 cites W1982359145 @default.
• W2566071722 cites W1991994507 @default.
• W2566071722 cites W1994541954 @default.
• W2566071722 cites W2004361323 @default.
• W2566071722 cites W2006214856 @default.
• W2566071722 cites W2012498962 @default.
• W2566071722 cites W2016331817 @default.
• W2566071722 cites W2019843278 @default.
• W2566071722 cites W2024813851 @default.
• W2566071722 cites W2027474692 @default.
• W2566071722 cites W2033873142 @default.
• W2566071722 cites W2034202087 @default.
• W2566071722 cites W2035771990 @default.
• W2566071722 cites W2045102424 @default.
• W2566071722 cites W2057384620 @default.
• W2566071722 cites W2059744004 @default.
• W2566071722 cites W2066571367 @default.
• W2566071722 cites W2066742589 @default.
• W2566071722 cites W2067005837 @default.
• W2566071722 cites W2068099929 @default.
• W2566071722 cites W2069504684 @default.
• W2566071722 cites W2084707538 @default.
• W2566071722 cites W2086290282 @default.
• W2566071722 cites W2094731304 @default.
• W2566071722 cites W2097195870 @default.
• W2566071722 cites W2102322990 @default.
• W2566071722 cites W2104990071 @default.
• W2566071722 cites W2121713067 @default.
• W2566071722 cites W2123697265 @default.
• W2566071722 cites W2125258716 @default.
• W2566071722 cites W2130792462 @default.
• W2566071722 cites W2144354629 @default.
• W2566071722 cites W2144685793 @default.
• W2566071722 cites W2145812083 @default.
• W2566071722 cites W2146885685 @default.
• W2566071722 cites W2154291487 @default.
• W2566071722 cites W2166712005 @default.
• W2566071722 cites W2188651990 @default.
• W2566071722 cites W2467837446 @default.
• W2566071722 cites W624999968 @default.
• W2566071722 doi "https://doi.org/10.1371/journal.pone.0167908" @default.
• W2566071722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5152834" @default.
• W2566071722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27941998" @default.
• W2566071722 hasPublicationYear "2016" @default.
• W2566071722 type Work @default.
• W2566071722 sameAs 2566071722 @default.
• W2566071722 citedByCount "10" @default.
• W2566071722 countsByYear W25660717222018 @default.
• W2566071722 countsByYear W25660717222019 @default.
• W2566071722 countsByYear W25660717222020 @default.
• W2566071722 countsByYear W25660717222021 @default.
• W2566071722 countsByYear W25660717222022 @default.
• W2566071722 countsByYear W25660717222023 @default.
• W2566071722 crossrefType "journal-article" @default.
• W2566071722 hasAuthorship W2566071722A5023224774 @default.
• W2566071722 hasAuthorship W2566071722A5048309955 @default.
• W2566071722 hasAuthorship W2566071722A5048818386 @default.
• W2566071722 hasAuthorship W2566071722A5051900412 @default.
• W2566071722 hasAuthorship W2566071722A5076901473 @default.
• W2566071722 hasAuthorship W2566071722A5088907366 @default.
• W2566071722 hasBestOaLocation W25660717221 @default.
• W2566071722 hasConcept C104317684 @default.
• W2566071722 hasConcept C146587185 @default.
• W2566071722 hasConcept C147447768 @default.
• W2566071722 hasConcept C153911025 @default.
• W2566071722 hasConcept C185592680 @default.
• W2566071722 hasConcept C190283241 @default.
• W2566071722 hasConcept C200784783 @default.
• W2566071722 hasConcept C203014093 @default.
• W2566071722 hasConcept C204232928 @default.
• W2566071722 hasConcept C2779058106 @default.
• W2566071722 hasConcept C2779072444 @default.
• W2566071722 hasConcept C28859421 @default.
• W2566071722 hasConcept C547475151 @default.
• W2566071722 hasConcept C55493867 @default.
• W2566071722 hasConcept C86803240 @default.
• W2566071722 hasConcept C95444343 @default.
• W2566071722 hasConceptScore W2566071722C104317684 @default.

• next