FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2566072440> ?p ?o ?g. }

• W2566072440 endingPage "119" @default.
• W2566072440 startingPage "111" @default.
• W2566072440 abstract "The interleukin-1 receptor-associated kinase-1 (IRAK-1) is an important adapter protein which links downstream of MyD88, and involved in the complex composed of MyD88 and TRAF6 to activate TLRs signaling pathway. In this study, an IRAK-1 homolog (FpIRAK-1) was cloned from the red tail shrimp Fenneropenaeus penicillatus. The ORF of FpIRAK-1 consisted of 2874 bp encoding a protein of 957 amino acids which contains a death domain (DD) and a catalytic domain of serine/threonine kinases (STKc). Homology analysis revealed that the predicted amino acid sequence of FpIRAK-1 shared 71% similarities with IRAK-1 of Litopenaeus vannamei. Real-time RT-PCR indicated that FpIRAK-1 was constitutively expressed in various tissues of F. penicillatus. The expression level of FpIRAK-1 mRNA was significantly up-regulated and then decreased gradually after white spot syndrome virus (WSSV) and Vibrio alginolyticus challenge. Gene knockdown of FpIRAK-1 enhanced the sensitivity of shrimps to WSSV and V. alginolyticus challenge, suggesting FpIRAK-1 could play a positive role against bacterial and viral pathogens. In conclusion, the results of this study provide some insights into the function of FpIRAK-1 in activating Toll signaling pathway and the host defense against invading pathogens." @default.
• W2566072440 created "2017-01-06" @default.
• W2566072440 creator A5007919436 @default.
• W2566072440 creator A5032588826 @default.
• W2566072440 creator A5080434891 @default.
• W2566072440 date "2017-02-01" @default.
• W2566072440 modified "2023-10-16" @default.
• W2566072440 title "Characterization and function analysis of interleukin-1 receptor-associated kinase-1 (IRAK-1) from Fenneropenaeus penicillatus" @default.
• W2566072440 cites W1513451813 @default.
• W2566072440 cites W1803235449 @default.
• W2566072440 cites W1968336033 @default.
• W2566072440 cites W1974755908 @default.
• W2566072440 cites W1975764495 @default.
• W2566072440 cites W1993060055 @default.
• W2566072440 cites W1993161572 @default.
• W2566072440 cites W1995586746 @default.
• W2566072440 cites W2004739382 @default.
• W2566072440 cites W2007092345 @default.
• W2566072440 cites W2011211995 @default.
• W2566072440 cites W2012170821 @default.
• W2566072440 cites W2024463933 @default.
• W2566072440 cites W2028222809 @default.
• W2566072440 cites W2040808444 @default.
• W2566072440 cites W2053523690 @default.
• W2566072440 cites W2057069307 @default.
• W2566072440 cites W2060923945 @default.
• W2566072440 cites W2064434771 @default.
• W2566072440 cites W2067720070 @default.
• W2566072440 cites W2073742636 @default.
• W2566072440 cites W2077714833 @default.
• W2566072440 cites W2080741149 @default.
• W2566072440 cites W2093629959 @default.
• W2566072440 cites W2098083707 @default.
• W2566072440 cites W2098915990 @default.
• W2566072440 cites W2107277218 @default.
• W2566072440 cites W2132632499 @default.
• W2566072440 cites W2134847649 @default.
• W2566072440 cites W2140795762 @default.
• W2566072440 cites W2150324671 @default.
• W2566072440 cites W2163558504 @default.
• W2566072440 cites W2171545875 @default.
• W2566072440 doi "https://doi.org/10.1016/j.fsi.2016.12.030" @default.
• W2566072440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28025158" @default.
• W2566072440 hasPublicationYear "2017" @default.
• W2566072440 type Work @default.
• W2566072440 sameAs 2566072440 @default.
• W2566072440 citedByCount "13" @default.
• W2566072440 countsByYear W25660724402017 @default.
• W2566072440 countsByYear W25660724402018 @default.
• W2566072440 countsByYear W25660724402019 @default.
• W2566072440 countsByYear W25660724402020 @default.
• W2566072440 countsByYear W25660724402021 @default.
• W2566072440 countsByYear W25660724402023 @default.
• W2566072440 crossrefType "journal-article" @default.
• W2566072440 hasAuthorship W2566072440A5007919436 @default.
• W2566072440 hasAuthorship W2566072440A5032588826 @default.
• W2566072440 hasAuthorship W2566072440A5080434891 @default.
• W2566072440 hasConcept C104317684 @default.
• W2566072440 hasConcept C11960822 @default.
• W2566072440 hasConcept C143065580 @default.
• W2566072440 hasConcept C153911025 @default.
• W2566072440 hasConcept C184235292 @default.
• W2566072440 hasConcept C190283241 @default.
• W2566072440 hasConcept C2776154503 @default.
• W2566072440 hasConcept C2776414213 @default.
• W2566072440 hasConcept C2778968793 @default.
• W2566072440 hasConcept C2779004061 @default.
• W2566072440 hasConcept C2779771762 @default.
• W2566072440 hasConcept C31573885 @default.
• W2566072440 hasConcept C32619005 @default.
• W2566072440 hasConcept C523546767 @default.
• W2566072440 hasConcept C54355233 @default.
• W2566072440 hasConcept C62478195 @default.
• W2566072440 hasConcept C86803240 @default.
• W2566072440 hasConcept C95444343 @default.
• W2566072440 hasConceptScore W2566072440C104317684 @default.
• W2566072440 hasConceptScore W2566072440C11960822 @default.
• W2566072440 hasConceptScore W2566072440C143065580 @default.
• W2566072440 hasConceptScore W2566072440C153911025 @default.
• W2566072440 hasConceptScore W2566072440C184235292 @default.
• W2566072440 hasConceptScore W2566072440C190283241 @default.
• W2566072440 hasConceptScore W2566072440C2776154503 @default.
• W2566072440 hasConceptScore W2566072440C2776414213 @default.
• W2566072440 hasConceptScore W2566072440C2778968793 @default.
• W2566072440 hasConceptScore W2566072440C2779004061 @default.
• W2566072440 hasConceptScore W2566072440C2779771762 @default.
• W2566072440 hasConceptScore W2566072440C31573885 @default.
• W2566072440 hasConceptScore W2566072440C32619005 @default.
• W2566072440 hasConceptScore W2566072440C523546767 @default.
• W2566072440 hasConceptScore W2566072440C54355233 @default.
• W2566072440 hasConceptScore W2566072440C62478195 @default.
• W2566072440 hasConceptScore W2566072440C86803240 @default.
• W2566072440 hasConceptScore W2566072440C95444343 @default.
• W2566072440 hasFunder F4320321001 @default.
• W2566072440 hasFunder F4320335795 @default.
• W2566072440 hasLocation W25660724401 @default.
• W2566072440 hasLocation W25660724402 @default.
• W2566072440 hasOpenAccess W2566072440 @default.

• next