FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2566077560> ?p ?o ?g. }

• W2566077560 abstract "Abstract A novel strategy for controlling the spread of arboviral diseases such as dengue, Zika and chikungunya is to transform mosquito populations with virus-suppressing Wolbaehia . In general, Wolbachia transinfected into mosquitoes induce fitness costs through lower viability or fecundity. These maternally inherited bacteria also produce a frequency-dependent advantage for infected females by inducing cytoplasmic incompatibility (CI), which kills the embryos produced by uninfected females mated to infected males. These competing effects, a frequency-dependent advantage and frequency-independent costs, produce bistable Wolbachia frequency dynamics. Above a threshold frequency, denoted p ̂ , CI drives fitness-decreasing Wolbachia transinfections through local populations; but below p ̂ , infection frequencies tend to decline to zero. If p ̂ is not too high, CI also drives spatial spread once infections become established over sufficiently large areas. We illustrate how simple models provide testable predictions concerning the spatial and temporal dynamics of Wolbachia introductions, focusing on rate of spatial spread, the shape of spreading waves, and the conditions for initiating spread from local introductions. First, we consider the robustness of diffusion-based predictions to incorporating two important features of wMel-Aedes aegypti biology that may be inconsistent with the diffusion approximations, namely fast local dynamics induced by complete CI ( i.e ., all embryos produced from incompatible crosses die) and long-tailed, non-Gaussian dispersal. With complete CI, our numerical analyses show that long-tailed dispersal changes wave-width predictions only slightly; but it can significantly reduce wave speed relative to the diffusion prediction; it also allows smaller local introductions to initiate spatial spread. Second, we use approximations for p̂ and dispersal distances to predict the outcome of 2013 releases of w Mel-infected Aedes aegypti in Cairns, Australia, Third, we describe new data from Aedes aegypti populations near Cairns, Australia that demonstrate long-distance dispersal and provide an approximate lower bound on p ̂ for w Mel in northeastern Australia. Finally, we apply our analyses to produce operational guidelines for efficient transformation of vector populations over large areas. We demonstrate that even very slow spatial spread, on the order of 10-20 m/month (as predicted), can produce area-wide population transformation within a few years following initial releases covering about 20-30% of the target area." @default.
• W2566077560 created "2017-01-06" @default.
• W2566077560 creator A5049856888 @default.
• W2566077560 creator A5049977531 @default.
• W2566077560 date "2016-12-11" @default.
• W2566077560 modified "2023-10-16" @default.
• W2566077560 title "Deploying dengue-suppressing Wolbachia: robust models predict slow but effective spatial spread in Aedes aegypti" @default.
• W2566077560 cites W1967945218 @default.
• W2566077560 cites W1968729839 @default.
• W2566077560 cites W1974161645 @default.
• W2566077560 cites W1974320139 @default.
• W2566077560 cites W1978933919 @default.
• W2566077560 cites W1990863491 @default.
• W2566077560 cites W1992312556 @default.
• W2566077560 cites W2003268306 @default.
• W2566077560 cites W2004681300 @default.
• W2566077560 cites W2005598927 @default.
• W2566077560 cites W2011148871 @default.
• W2566077560 cites W2017971345 @default.
• W2566077560 cites W2021528867 @default.
• W2566077560 cites W2022851429 @default.
• W2566077560 cites W2029489942 @default.
• W2566077560 cites W2033102981 @default.
• W2566077560 cites W2034017401 @default.
• W2566077560 cites W2034492280 @default.
• W2566077560 cites W2038739365 @default.
• W2566077560 cites W2041912506 @default.
• W2566077560 cites W2044918464 @default.
• W2566077560 cites W2046673952 @default.
• W2566077560 cites W2047526274 @default.
• W2566077560 cites W2048471787 @default.
• W2566077560 cites W2052469852 @default.
• W2566077560 cites W2053172669 @default.
• W2566077560 cites W2058158148 @default.
• W2566077560 cites W2059597623 @default.
• W2566077560 cites W2065796860 @default.
• W2566077560 cites W2066490392 @default.
• W2566077560 cites W2069937826 @default.
• W2566077560 cites W2071101791 @default.
• W2566077560 cites W2071621000 @default.
• W2566077560 cites W2071986366 @default.
• W2566077560 cites W2075519966 @default.
• W2566077560 cites W2075911100 @default.
• W2566077560 cites W2079368196 @default.
• W2566077560 cites W2088779467 @default.
• W2566077560 cites W2089902221 @default.
• W2566077560 cites W2092133388 @default.
• W2566077560 cites W2098594887 @default.
• W2566077560 cites W2108077860 @default.
• W2566077560 cites W2117725271 @default.
• W2566077560 cites W2120477979 @default.
• W2566077560 cites W2132192579 @default.
• W2566077560 cites W2136062469 @default.
• W2566077560 cites W2137409269 @default.
• W2566077560 cites W2138983267 @default.
• W2566077560 cites W2150290251 @default.
• W2566077560 cites W2150604056 @default.
• W2566077560 cites W2150650344 @default.
• W2566077560 cites W2152146452 @default.
• W2566077560 cites W2162102381 @default.
• W2566077560 cites W2170899148 @default.
• W2566077560 cites W2172111809 @default.
• W2566077560 cites W2181263624 @default.
• W2566077560 cites W2278298161 @default.
• W2566077560 cites W2594244343 @default.
• W2566077560 cites W2594916508 @default.
• W2566077560 cites W4232355219 @default.
• W2566077560 cites W4240810596 @default.
• W2566077560 doi "https://doi.org/10.1101/093229" @default.
• W2566077560 hasPublicationYear "2016" @default.
• W2566077560 type Work @default.
• W2566077560 sameAs 2566077560 @default.
• W2566077560 citedByCount "0" @default.
• W2566077560 crossrefType "posted-content" @default.
• W2566077560 hasAuthorship W2566077560A5049856888 @default.
• W2566077560 hasAuthorship W2566077560A5049977531 @default.
• W2566077560 hasBestOaLocation W25660775601 @default.
• W2566077560 hasConcept C126831891 @default.
• W2566077560 hasConcept C144024400 @default.
• W2566077560 hasConcept C147532639 @default.
• W2566077560 hasConcept C149923435 @default.
• W2566077560 hasConcept C159047783 @default.
• W2566077560 hasConcept C168456226 @default.
• W2566077560 hasConcept C173758957 @default.
• W2566077560 hasConcept C180478619 @default.
• W2566077560 hasConcept C18903297 @default.
• W2566077560 hasConcept C22508944 @default.
• W2566077560 hasConcept C2777775583 @default.
• W2566077560 hasConcept C2779356413 @default.
• W2566077560 hasConcept C2781273456 @default.
• W2566077560 hasConcept C2908647359 @default.
• W2566077560 hasConcept C47559259 @default.
• W2566077560 hasConcept C533803919 @default.
• W2566077560 hasConcept C59822182 @default.
• W2566077560 hasConcept C67283656 @default.
• W2566077560 hasConcept C86803240 @default.
• W2566077560 hasConcept C90856448 @default.
• W2566077560 hasConceptScore W2566077560C126831891 @default.
• W2566077560 hasConceptScore W2566077560C144024400 @default.
• W2566077560 hasConceptScore W2566077560C147532639 @default.

• next