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- W2566077825 abstract "OBJECTIVETo describe the clinical and initial neuroradiological manifestations of patients in an outbreak of group B streptococcal (GBS) meningitis.BACKGROUNDSince Dec 2014, many healthy non-pregnant adult patients with GBS infection were identified in Singapore; the outbreak was thought to be related to consuming infected raw fish.DESIGN/METHODSThe database of the Singapore Neurologic Infections Program (SNIP), a national multicentre study for surveillance of infectious neurologic disease, was reviewed to select patients with GBS central nervous system (CNS) infection during the outbreak. Cases were diagnosed on the basis of clinical features, cerebrospinal fluid (CSF) findings and identification or isolation of Streptococcus agalactiae in the blood or CSF. Demographic, clinical and neuroradiological information was obtained prospectively and abstracted.RESULTSFourteen patients (6 male, 8 female) were identified; median age at disease onset was 58 years (range 22 to 81). Common presenting symptoms included fever (100[percnt]), meningism (57[percnt]), headache (50[percnt]), encephalopathy (43[percnt]), focal neurological deficits (36[percnt]) and seizures (14[percnt]). All patients were community-dwelling and previously healthy except for 2 with diabetes mellitus (one patient had previous breast carcinoma), and 1 each with childhood epilepsy and previous meningoencephalitis. Diffusion-weighted MRI was abnormal in 13 patients, showing tiny hyperintensities in the subarachnoid space and ventricles in 9 patients, as well as larger lesions within the brain parenchyma in 8 patients. Five had cerebellar abnormalities.CONCLUSIONS/RELEVANCEAmong adults infected with GBS meningitis, diffusion-weighted MRI was helpful in detecting small subarachnoid, ventricular and brain lesions, including cerebellar involvement. A collaborative national surveillance system can be helpful for detecting outbreaks of unusual CNS infections. Disclosure: Dr. Tan has nothing to disclose. Dr. Wijaya has nothing to disclose. Dr. Chiew has nothing to disclose. Dr. Sitoh has nothing to disclose. Dr. Shafi has nothing to disclose. Dr. Chen has nothing to disclose. Dr. Goh has nothing to disclose. Dr. Lim has nothing to disclose." @default.
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- W2566077825 date "2016-04-05" @default.
- W2566077825 modified "2023-09-26" @default.
- W2566077825 title "An outbreak of Group B Streptococcal CNS infection in Singapore: unusual clinical and MRI findings (P1.330)" @default.
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