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- W2566081289 abstract "Abstract The protective potential of pomegranate ( Punica granatum L.) mesocarp extract (PME) on a cell model mimicking diabetes-like oxidative stress exposed to advanced glycation end products (AGEs) and hydrogen peroxide (H 2 O 2 ) was investigated. The polyphenolic antioxidant rich PME afforded protection to erythrocytes from AAPH radical-induced lysis and significantly reduced (P NOX1 expression. PME significantly inhibited protein carbonyl and AOPP levels following their increase in the presence of AGEs and H 2 O 2 (P . It exerted an anti-inflammatory effect on preadipocytes by suppressing IL-6 secretion. PME down-regulated the over-expression of pro-inflammatory mediators NFκB , iNOS and IL-6 post-AGEs treatment and concomitantly down-regulated the expression of AGEs receptor CD36 in the presence of AGEs. PME decreases oxidative stress and inflammation at adipose tissue level with the propensity to mitigate obesity-related disorders such as insulin resistance and type II diabetes." @default.
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- W2566081289 date "2017-02-01" @default.
- W2566081289 modified "2023-09-25" @default.
- W2566081289 title "Punica granatum L. mesocarp suppresses advanced glycation end products (AGEs)- and H 2 O 2 -induced oxidative stress and pro-inflammatory biomarkers" @default.
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- W2566081289 doi "https://doi.org/10.1016/j.jff.2016.12.007" @default.
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