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- W2566179610 abstract "As it has been proved by recent studies, asthma may lead to the development of obstructive sleep apnea (OSA). However, there are little data available on interrelation between OSA and airway hyperresponsiveness (AHR) as one of the main asthma hallmarks. Objective: The aim of the study was to evaluate mutual influence of AHR and OSA in patient with asthma. Methods: 122 patients diagnosed with asthma (mean age 42.5±1.07) underwent spirometry before and after the challenges with 3-minute isocapnic cold air hyperventilation, 3-minute ventilation with ultrasonically nebulized distilled water, and tests for reversibility of airflow limitation with salbutamol and ipratropium. Results: OSA was diagnosed in 31.9% of all subjects. Patients with OSA had more excessive responses (ΔFEV1) to inhalation of cold air (-13 (-17; -5) vs. -3.8 (-7.8; -0.01), p=0.001), distilled water (-9.7 (-12.5; -5.7) vs. -4 (-7.1; -1.5), p Conclusion: The obtained data suggest mutual burdening of OSA and AHR that appears as an increase of AHI in patients with AHR and higher grade of AHR in OSA." @default.
- W2566179610 created "2017-01-06" @default.
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- W2566179610 date "2015-09-01" @default.
- W2566179610 modified "2023-09-27" @default.
- W2566179610 title "Mutual influense of airway hyperresponsiveness and obstructive sleep apnea in patients with asthma" @default.
- W2566179610 doi "https://doi.org/10.1183/13993003.congress-2015.pa2387" @default.
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