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• W2566291361 abstract "The role of nitric oxide and its reactive derivatives (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>N</mml:mi><mml:mi mathvariant=normal>O</mml:mi></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>) is well known in the pathogenesis of multiple sclerosis, which is an inflammatory disease while<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>N</mml:mi><mml:mi mathvariant=normal>O</mml:mi></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>seems to be important in coordinating inflammatory response. The purpose of the present study was to assess serum<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>N</mml:mi><mml:mi mathvariant=normal>O</mml:mi></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>as one of the nitrogen species and inflammatory parameters in relapsing-remitting multiple sclerosis patients and to compare the effectiveness of various types of disease-modifying therapies that reduce nitric oxide and inflammatory biomarkers. Elevated<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>N</mml:mi><mml:mi mathvariant=normal>O</mml:mi></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>level was observed in patients who received the first-line disease-modifying therapy (interferons beta-1a and beta-1b) in comparison with the subjects treated with the second-line disease-modifying therapy (natalizumab; fingolimod) and healthy controls without significant differences in C-reactive protein and interleukin-1 beta. A negative correlation was observed between serum<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>N</mml:mi><mml:mi mathvariant=normal>O</mml:mi></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>level and the duration of multiple sclerosis confirmed in the whole study population and in subjects treated with the first-line agents. Only serum<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>N</mml:mi><mml:mi mathvariant=normal>O</mml:mi></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>, concentration could reveal a potential efficacy of disease-modifying therapy with a better reduction in<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>N</mml:mi><mml:mi mathvariant=normal>O</mml:mi></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>level due to the second-line agents of disease-modifying therapy." @default.
• W2566291361 created "2017-01-06" @default.
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• W2566291361 date "2016-01-01" @default.
• W2566291361 modified "2023-09-27" @default.
• W2566291361 title "Assessment of Serum Nitrogen Species and Inflammatory Parameters in Relapsing-Remitting Multiple Sclerosis Patients Treated with Different Therapeutic Approaches" @default.
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• W2566291361 doi "https://doi.org/10.1155/2016/4570351" @default.
• W2566291361 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5204117" @default.
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• W2566291361 hasPublicationYear "2016" @default.
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