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- W2566331545 startingPage "37" @default.
- W2566331545 abstract "Pediatric cancers rarely exhibit recurrent mutational events when compared to most adult cancers. This poses a challenge in understanding how cancers initiate, progress, and metastasize in early childhood. Also, due to limited detected driver mutations, it is difficult to benchmark key genes for drug development. In this review, we use neuroblastoma, a pediatric solid tumor of neural crest origin, as a paradigm for exploring “big data” applications in pediatric oncology. Computational strategies derived from big data science–network- and machine learning-based modeling and drug repositioning—hold the promise of shedding new light on the molecular mechanisms driving neuroblastoma pathogenesis and identifying potential therapeutics to combat this devastating disease. These strategies integrate robust data input, from genomic and transcriptomic studies, clinical data, and in vivo and in vitro experimental models specific to neuroblastoma and other types of cancers that closely mimic its biological characteristics. We discuss contexts in which “big data” and computational approaches, especially network-based modeling, may advance neuroblastoma research, describe currently available data and resources, and propose future models of strategic data collection and analyses for neuroblastoma and other related diseases." @default.
- W2566331545 created "2017-01-06" @default.
- W2566331545 creator A5012875471 @default.
- W2566331545 creator A5051724671 @default.
- W2566331545 creator A5060702229 @default.
- W2566331545 creator A5072127156 @default.
- W2566331545 date "2016-12-27" @default.
- W2566331545 modified "2023-10-02" @default.
- W2566331545 title "Neuroblastoma, a Paradigm for Big Data Science in Pediatric Oncology" @default.
- W2566331545 cites W1019830208 @default.
- W2566331545 cites W1169245016 @default.
- W2566331545 cites W120037188 @default.
- W2566331545 cites W1502410692 @default.
- W2566331545 cites W1505191356 @default.
- W2566331545 cites W1512398642 @default.
- W2566331545 cites W1514592277 @default.
- W2566331545 cites W1558704041 @default.
- W2566331545 cites W1571073982 @default.
- W2566331545 cites W1575126878 @default.
- W2566331545 cites W1600824865 @default.
- W2566331545 cites W1782329891 @default.
- W2566331545 cites W1826266252 @default.
- W2566331545 cites W1838829111 @default.
- W2566331545 cites W1859714693 @default.
- W2566331545 cites W1906165854 @default.
- W2566331545 cites W1910421424 @default.
- W2566331545 cites W1914507546 @default.
- W2566331545 cites W1915238740 @default.
- W2566331545 cites W1949900168 @default.
- W2566331545 cites W1964861583 @default.
- W2566331545 cites W1966505629 @default.
- W2566331545 cites W1968530152 @default.
- W2566331545 cites W1971661699 @default.
- W2566331545 cites W1971828608 @default.
- W2566331545 cites W1973017365 @default.
- W2566331545 cites W1975255784 @default.
- W2566331545 cites W1976892175 @default.
- W2566331545 cites W1978493152 @default.
- W2566331545 cites W1978710835 @default.
- W2566331545 cites W1979003656 @default.
- W2566331545 cites W1979026812 @default.
- W2566331545 cites W1980763900 @default.
- W2566331545 cites W1980943899 @default.
- W2566331545 cites W1986273621 @default.
- W2566331545 cites W1986680484 @default.
- W2566331545 cites W1987557775 @default.
- W2566331545 cites W1989996002 @default.
- W2566331545 cites W1991590017 @default.
- W2566331545 cites W1993702356 @default.
- W2566331545 cites W1993942967 @default.
- W2566331545 cites W1999798000 @default.
- W2566331545 cites W2001740805 @default.
- W2566331545 cites W2001949677 @default.
- W2566331545 cites W2003012985 @default.
- W2566331545 cites W2003366192 @default.
- W2566331545 cites W2006131916 @default.
- W2566331545 cites W2006417904 @default.
- W2566331545 cites W2009720434 @default.
- W2566331545 cites W2009871251 @default.
- W2566331545 cites W2010978319 @default.
- W2566331545 cites W2012404242 @default.
- W2566331545 cites W2019163655 @default.
- W2566331545 cites W2019751519 @default.
- W2566331545 cites W2020541351 @default.
- W2566331545 cites W2020882368 @default.
- W2566331545 cites W2022354436 @default.
- W2566331545 cites W2028831927 @default.
- W2566331545 cites W2029126296 @default.
- W2566331545 cites W2031983198 @default.
- W2566331545 cites W2032183472 @default.
- W2566331545 cites W2032452231 @default.
- W2566331545 cites W2033591223 @default.
- W2566331545 cites W2036370250 @default.
- W2566331545 cites W2038586807 @default.
- W2566331545 cites W2043398720 @default.
- W2566331545 cites W2044025814 @default.
- W2566331545 cites W2044033792 @default.
- W2566331545 cites W2044525257 @default.
- W2566331545 cites W2047569750 @default.
- W2566331545 cites W2047967134 @default.
- W2566331545 cites W2049445311 @default.
- W2566331545 cites W2049942970 @default.
- W2566331545 cites W2050661306 @default.
- W2566331545 cites W2052016211 @default.
- W2566331545 cites W2052801268 @default.
- W2566331545 cites W2053709166 @default.
- W2566331545 cites W2057312647 @default.
- W2566331545 cites W2062500929 @default.
- W2566331545 cites W2062533676 @default.
- W2566331545 cites W2063337289 @default.
- W2566331545 cites W2064013031 @default.
- W2566331545 cites W2068653396 @default.
- W2566331545 cites W2069173387 @default.
- W2566331545 cites W2070192320 @default.
- W2566331545 cites W2070602352 @default.
- W2566331545 cites W2073136316 @default.
- W2566331545 cites W2074926938 @default.
- W2566331545 cites W2079095609 @default.