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• W2566352018 abstract "Pulmonary arterial hypertension (PAH) is a lung vascular disease characterized with a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling resulting in right heart failure and premature death. In this brief review, we document the recent advances in identifying genetically modified murine models of PH, with a focus on the recent discovery of the mouse model of Tie2 Cre-mediated deletion of prolyl hydroxylase 2, which exhibits progressive obliterative vascular remodeling, severe PAH, and right heart failure, thus recapitulating many of the features of clinical PAH. We will also discuss the translational potential of recent findings arising from experimental studies of murine PH models." @default.
• W2566352018 created "2017-01-06" @default.
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• W2566352018 creator A5061188077 @default.
• W2566352018 date "2017-05-01" @default.
• W2566352018 modified "2023-09-27" @default.
• W2566352018 title "Discovery of a murine model of clinical PAH: Mission impossible?" @default.
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• W2566352018 doi "https://doi.org/10.1016/j.tcm.2016.12.003" @default.
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