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- W2566356150 abstract "Salmonellosis, caused by members of the genus Salmonella , is responsible for considerable global morbidity and mortality in both animals and humans. In this review, we will discuss the pathogenesis of Salmonella enterica serovar Typhi and Salmonella enterica serovar Typhimurium, focusing on human Salmonella infections. We will trace the path of Salmonella through the body, including host entry sites, tissues and organs affected, and mechanisms involved in both pathogenesis and stimulation of host immunity. Careful consideration of the natural progression of disease provides an important context in which attenuated live oral vaccines can be rationally designed and developed. With this in mind, we will describe a series of attenuated live oral vaccines that have been successfully tested in clinical trials and demonstrated to be both safe and highly immunogenic. The attenuation strategies summarized in this review offer important insights into further development of attenuated vaccines against other Salmonella for which live oral candidates are currently unavailable." @default.
- W2566356150 created "2017-01-06" @default.
- W2566356150 creator A5012200009 @default.
- W2566356150 creator A5033680334 @default.
- W2566356150 creator A5070409967 @default.
- W2566356150 creator A5088301664 @default.
- W2566356150 date "2016-01-11" @default.
- W2566356150 modified "2023-09-25" @default.
- W2566356150 title "Live Attenuated Human <i>Salmonella</i> Vaccine Candidates: Tracking the Pathogen in Natural Infection and Stimulation of Host Immunity" @default.
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