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- W2566385733 abstract "Studies in fish have reported the presence and function of fatty acid (FA)-sensing systems comparable in many aspects to those known in mammals. Such studies were carried out in juvenile and adult fish, but the presence of FA sensing systems and control of food intake has never been evaluated in early stages, despite the importance of establishing when appetite regulation becomes functional in larval fish. In this study we aimed to elucidate the possible effects of different specific FA on neural FA sensing systems and neuropeptides involved in the control of food intake in Senegalese sole post-larvae. To achieve this, we orally administered post-larvae with different solutions containing pure FA - oleate (OA), linoleate (LA), α-linolenate (ALA) or eicosapentaenoate (EPA) - and evaluated changes in mRNA abundance of neuropeptides involved in the control of food intake and of transcripts related to putative FA-sensing systems, 3 h and 6 h post-administration. Results of neuropeptide gene expression were relatively consistent with the activation of anorectic pathways (enhanced cart4 and pomcb) and decrease in orexigenic factors (npy) following intake of FA. Even if there were a few differences depending on the nature of the FA, the observed changes appear to suggest the existence of a putative anorectic response in fish post-larvae to the ingestion of all four tested FA. However, changes in neuropeptides cannot be explained by the integration of metabolic information of FA in circulation through FA sensing mechanisms in the brain. Only the reduction in mRNA levels of acc in OA- (6 h), ALA- (3 h) and EPA-treated (3 h and 6 h) post-larvae could be indicative of the presence of a FA sensing system, but most genes were either not significantly regulated (fat/cd36-lmp2, acly, kir6.x, srebp1c) or were affected (fat/cd36-pg4l, fas, cpt1.1, cpt1.2, cpt1.3, sur, pparα and lxrα) in a way inconsistent with FA sensing mechanisms." @default.
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- W2566385733 date "2016-01-01" @default.
- W2566385733 modified "2023-10-09" @default.
- W2566385733 title "Orally administrated fatty acids enhanced anorectic potential but did not activate central fatty acid sensing in Senegalese sole post-larvae" @default.
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- W2566385733 doi "https://doi.org/10.1242/jeb.150979" @default.
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