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• W2566387862 abstract "Significance Mutually beneficial interactions of fungi with bacteria are increasingly recognized as ubiquitous and economically important. However, little is known about their establishment and maintenance. Utilizing the association between the fungus Rhizopus microsporus and its endosymbiont Burkholderia as a model, we provide first insights into fungal molecular mechanisms governing symbiosis establishment with bacteria. We show that specific changes in fungal lipid metabolism, mediated by diacylgycerol kinase enzymes, are required to maintain a mutualistic outcome of interaction with bacteria, a pattern consistent with the addiction model of mutualism evolution. We also offer insights into genetics and biochemistry of lipid metabolism in an understudied group of oleaginous fungi, which are a promising source of oils for biodiesel production." @default.
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• W2566387862 date "2016-12-12" @default.
• W2566387862 modified "2023-10-15" @default.
• W2566387862 title "Lipid metabolic changes in an early divergent fungus govern the establishment of a mutualistic symbiosis with endobacteria" @default.
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• W2566387862 doi "https://doi.org/10.1073/pnas.1615148113" @default.
• W2566387862 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5206550" @default.
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