FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2566451260> ?p ?o ?g. }

• W2566451260 endingPage "1375" @default.
• W2566451260 startingPage "1365" @default.
• W2566451260 abstract "Abstract The role of IL-33, particularly in tumor growth and tumor immunity, remains ill-defined. We show that exogenous IL-33 can induce robust antitumor effect through a CD8+ T cell–dependent mechanism. Systemic administration of rIL-33 alone was sufficient to inhibit growth of established tumors in transplant and de novo melanoma tumorigenesis models. Notably, in addition to a direct action on CD8+ T cell expansion and IFN-γ production, rIL-33 therapy activated myeloid dendritic cells (mDCs) in tumor-bearing mice, restored antitumor T cell activity, and increased Ag cross-presentation within the tumor microenvironment. Furthermore, combination therapy consisting of rIL-33 and agonistic anti-CD40 Abs demonstrated synergistic antitumor activity. Specifically, MyD88, an essential component of the IL-33 signaling pathway, was required for the IL-33–mediated increase in mDC number and upregulation in expression of costimulatory molecules. Importantly, we identified that the IL-33 receptor ST2, MyD88, and STAT1 cooperate to induce costimulatory molecule expression on mDCs in response to rIL-33. Thus, our study revealed a novel IL-33–ST2–MyD88–STAT1 axis that restores mDC activation and maturation in established cancer and, thereby, the magnitude of antitumor immune responses, suggesting a potential use of rIL-33 as a new immunotherapy option to treat established cancer." @default.
• W2566451260 created "2017-01-06" @default.
• W2566451260 creator A5003177689 @default.
• W2566451260 creator A5003529094 @default.
• W2566451260 creator A5016537493 @default.
• W2566451260 creator A5024431895 @default.
• W2566451260 creator A5029634246 @default.
• W2566451260 creator A5043224088 @default.
• W2566451260 creator A5044544424 @default.
• W2566451260 creator A5046881277 @default.
• W2566451260 creator A5049990875 @default.
• W2566451260 creator A5057730293 @default.
• W2566451260 creator A5060788268 @default.
• W2566451260 creator A5085292829 @default.
• W2566451260 creator A5090385327 @default.
• W2566451260 date "2017-02-01" @default.
• W2566451260 modified "2023-09-30" @default.
• W2566451260 title "Exogenous IL-33 Restores Dendritic Cell Activation and Maturation in Established Cancer" @default.
• W2566451260 cites W1529833805 @default.
• W2566451260 cites W1566335138 @default.
• W2566451260 cites W1616344155 @default.
• W2566451260 cites W1898853267 @default.
• W2566451260 cites W1916446105 @default.
• W2566451260 cites W1937682064 @default.
• W2566451260 cites W1944675847 @default.
• W2566451260 cites W1948324417 @default.
• W2566451260 cites W1968955229 @default.
• W2566451260 cites W1970195561 @default.
• W2566451260 cites W1975075371 @default.
• W2566451260 cites W1983312277 @default.
• W2566451260 cites W1984484036 @default.
• W2566451260 cites W1987257733 @default.
• W2566451260 cites W1988035869 @default.
• W2566451260 cites W1989093336 @default.
• W2566451260 cites W2001316686 @default.
• W2566451260 cites W2002892444 @default.
• W2566451260 cites W2004066105 @default.
• W2566451260 cites W2007810913 @default.
• W2566451260 cites W2012826189 @default.
• W2566451260 cites W2013523148 @default.
• W2566451260 cites W2014171507 @default.
• W2566451260 cites W2026572617 @default.
• W2566451260 cites W2031633372 @default.
• W2566451260 cites W2036675396 @default.
• W2566451260 cites W2042911811 @default.
• W2566451260 cites W2045994086 @default.
• W2566451260 cites W2050067847 @default.
• W2566451260 cites W2051117154 @default.
• W2566451260 cites W2053849689 @default.
• W2566451260 cites W2058235432 @default.
• W2566451260 cites W2063557080 @default.
• W2566451260 cites W2068971398 @default.
• W2566451260 cites W2079140075 @default.
• W2566451260 cites W2080449595 @default.
• W2566451260 cites W2087924251 @default.
• W2566451260 cites W2091617195 @default.
• W2566451260 cites W2099355322 @default.
• W2566451260 cites W2121686426 @default.
• W2566451260 cites W2124039716 @default.
• W2566451260 cites W2127132608 @default.
• W2566451260 cites W2129088290 @default.
• W2566451260 cites W2131877903 @default.
• W2566451260 cites W2131974963 @default.
• W2566451260 cites W2145149316 @default.
• W2566451260 cites W2155432151 @default.
• W2566451260 cites W2156106286 @default.
• W2566451260 cites W2157710399 @default.
• W2566451260 cites W2163984243 @default.
• W2566451260 cites W2164396254 @default.
• W2566451260 cites W2166623795 @default.
• W2566451260 cites W2167557705 @default.
• W2566451260 cites W2168381900 @default.
• W2566451260 cites W2169692356 @default.
• W2566451260 doi "https://doi.org/10.4049/jimmunol.1501399" @default.
• W2566451260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5263113" @default.
• W2566451260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28011934" @default.
• W2566451260 hasPublicationYear "2017" @default.
• W2566451260 type Work @default.
• W2566451260 sameAs 2566451260 @default.
• W2566451260 citedByCount "74" @default.
• W2566451260 countsByYear W25664512602017 @default.
• W2566451260 countsByYear W25664512602018 @default.
• W2566451260 countsByYear W25664512602019 @default.
• W2566451260 countsByYear W25664512602020 @default.
• W2566451260 countsByYear W25664512602021 @default.
• W2566451260 countsByYear W25664512602022 @default.
• W2566451260 countsByYear W25664512602023 @default.
• W2566451260 crossrefType "journal-article" @default.
• W2566451260 hasAuthorship W2566451260A5003177689 @default.
• W2566451260 hasAuthorship W2566451260A5003529094 @default.
• W2566451260 hasAuthorship W2566451260A5016537493 @default.
• W2566451260 hasAuthorship W2566451260A5024431895 @default.
• W2566451260 hasAuthorship W2566451260A5029634246 @default.
• W2566451260 hasAuthorship W2566451260A5043224088 @default.
• W2566451260 hasAuthorship W2566451260A5044544424 @default.
• W2566451260 hasAuthorship W2566451260A5046881277 @default.
• W2566451260 hasAuthorship W2566451260A5049990875 @default.
• W2566451260 hasAuthorship W2566451260A5057730293 @default.

• next