FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2566457427> ?p ?o ?g. }

• W2566457427 endingPage "348" @default.
• W2566457427 startingPage "339" @default.
• W2566457427 abstract "Summary Venous thromboembolism is a major cause of death during and immediately post-sepsis. Venous thrombosis (VT) is mediated by cell adhesion molecules and leukocytes, including neutrophil extracellular traps (NETs). Sepsis, or experimentally, endotoxaemia, shares similar characteristics and is modulated via toll like receptor 4 (TLR4). This study was undertaken to determine if endotoxaemia potentiates early stasis thrombogenesis, and secondarily to determine the role of VT TLR4, ICAM-1 and neutrophils (PMNs). Wild-type (WT), ICAM-1-/- and TLR4-/- mice underwent treatment with saline or LPS (10 mg/kg i.p.) alone, or followed by inferior vena cava (IVC) ligation to generate stasis VT. In vivo microscopy of leukocyte trafficking was performed in non-thrombosed mice, and tissue and plasma were harvested during early VT formation. Pre-thrombosis, circulating ICAM-1 was elevated and increased leukocyte adhesion and rolling occurred on the IVC of LPS-treated mice. Post-thrombosis, endotoxaemic mice formed larger, platelet-poor thrombi. Endotoxaemic TLR4-/- mice did not have an augmented thrombotic response and exhibited significantly decreased circulating ICAM-1 compared to endotoxaemic WT controls. Endotoxaemic ICAM-1-/- mice had significantly smaller thrombi compared to controls. Hypothesising that PMNs localised to the inflamed endothelium were promoting thrombosis, PMN depletion using anti-Ly6G antibody was performed. Paradoxically, VT formed without PMNs was amplified, potentially related to endotoxaemia induced elevation of PAI-1 and circulating FXIII, and decreased uPA. Endotoxaemia enhanced early VT occurs in a TLR-4 and ICAM-1 dependent fashion, and is potentiated by neutropenia. ICAM-1 and/or TLR-4 inhibition may be a unique strategy to prevent sepsis-associated VT. Supplementary Material to this article is available online at www.thrombosis-online.com." @default.
• W2566457427 created "2017-01-06" @default.
• W2566457427 creator A5003956897 @default.
• W2566457427 creator A5033268794 @default.
• W2566457427 creator A5035255903 @default.
• W2566457427 creator A5048388779 @default.
• W2566457427 creator A5052342876 @default.
• W2566457427 creator A5058935102 @default.
• W2566457427 creator A5061151551 @default.
• W2566457427 creator A5070481231 @default.
• W2566457427 creator A5075997575 @default.
• W2566457427 creator A5082274185 @default.
• W2566457427 date "2017-01-01" @default.
• W2566457427 modified "2023-10-01" @default.
• W2566457427 title "Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia" @default.
• W2566457427 cites W1483162601 @default.
• W2566457427 cites W1533637173 @default.
• W2566457427 cites W1600560134 @default.
• W2566457427 cites W1854917621 @default.
• W2566457427 cites W1862054033 @default.
• W2566457427 cites W192935245 @default.
• W2566457427 cites W1942574329 @default.
• W2566457427 cites W1967108695 @default.
• W2566457427 cites W1974655370 @default.
• W2566457427 cites W1978926805 @default.
• W2566457427 cites W1981821823 @default.
• W2566457427 cites W1986181143 @default.
• W2566457427 cites W1998861227 @default.
• W2566457427 cites W2002354857 @default.
• W2566457427 cites W2002880283 @default.
• W2566457427 cites W2008729605 @default.
• W2566457427 cites W2011416774 @default.
• W2566457427 cites W2014678245 @default.
• W2566457427 cites W2019952254 @default.
• W2566457427 cites W2027125446 @default.
• W2566457427 cites W2033228742 @default.
• W2566457427 cites W2037905113 @default.
• W2566457427 cites W2039453748 @default.
• W2566457427 cites W2039811018 @default.
• W2566457427 cites W2041503211 @default.
• W2566457427 cites W2045819100 @default.
• W2566457427 cites W2048027358 @default.
• W2566457427 cites W2050047890 @default.
• W2566457427 cites W2051634683 @default.
• W2566457427 cites W2062709947 @default.
• W2566457427 cites W2064369146 @default.
• W2566457427 cites W2064693934 @default.
• W2566457427 cites W2064973550 @default.
• W2566457427 cites W2070117107 @default.
• W2566457427 cites W2072268299 @default.
• W2566457427 cites W2074668545 @default.
• W2566457427 cites W2075211044 @default.
• W2566457427 cites W2076291626 @default.
• W2566457427 cites W2077996996 @default.
• W2566457427 cites W2095972654 @default.
• W2566457427 cites W2096703285 @default.
• W2566457427 cites W2098469346 @default.
• W2566457427 cites W2102424826 @default.
• W2566457427 cites W2106296789 @default.
• W2566457427 cites W2110827592 @default.
• W2566457427 cites W2114766509 @default.
• W2566457427 cites W2118459007 @default.
• W2566457427 cites W2120489016 @default.
• W2566457427 cites W2123467599 @default.
• W2566457427 cites W2125451492 @default.
• W2566457427 cites W2127259448 @default.
• W2566457427 cites W2133498102 @default.
• W2566457427 cites W2134053129 @default.
• W2566457427 cites W2134923719 @default.
• W2566457427 cites W2138212531 @default.
• W2566457427 cites W2141868068 @default.
• W2566457427 cites W2142102042 @default.
• W2566457427 cites W2145097136 @default.
• W2566457427 cites W2148993454 @default.
• W2566457427 cites W2152502508 @default.
• W2566457427 cites W2154649516 @default.
• W2566457427 cites W2155244284 @default.
• W2566457427 cites W2156334245 @default.
• W2566457427 cites W2163295664 @default.
• W2566457427 cites W2163466475 @default.
• W2566457427 cites W2169170199 @default.
• W2566457427 cites W2172191543 @default.
• W2566457427 cites W217628581 @default.
• W2566457427 cites W2182231447 @default.
• W2566457427 cites W2242893540 @default.
• W2566457427 cites W2460776291 @default.
• W2566457427 cites W2581605534 @default.
• W2566457427 cites W2620241325 @default.
• W2566457427 cites W3023757607 @default.
• W2566457427 cites W4214589643 @default.
• W2566457427 cites W4379136709 @default.
• W2566457427 cites W92044437 @default.
• W2566457427 doi "https://doi.org/10.1160/th16-03-0218" @default.
• W2566457427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5436925" @default.
• W2566457427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27975098" @default.
• W2566457427 hasPublicationYear "2017" @default.
• W2566457427 type Work @default.
• W2566457427 sameAs 2566457427 @default.

• next