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- W2566573769 abstract "Stimuli-responsive anticancer formulations can promote drug release and activation within the target tumour, facilitate cellular uptake, as well as improve the therapeutic efficacy of drugs and reduce off-target effects. In the present work, indocyanine green (ICG)-containing polyglutamate (PGA) nanoparticles were developed and characterized. Digestion of nanoparticles with cathepsin B, a matrix metalloproteinase overexpressed in the microenvironment of advanced tumours, decreased particle size and increased ICG cellular uptake. Incorporation of ICG in PGA nanoparticles provided the NIR-absorbing agent with time-dependent altered optical properties in the presence of cathepsin B. Having minimal dark toxicity, the formulation exhibited significant cytotoxicity upon NIR exposure. Combined use of the formulation with saporin, a ribosome-inactivating protein, resulted in synergistically enhanced cytotoxicity attributed to the photo-induced release of saporin from endo/lysosomes. The results suggest that this therapeutic approach can offer significant therapeutic benefit in the treatment of superficial malignancies, such as head and neck tumours." @default.
- W2566573769 created "2017-01-06" @default.
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- W2566573769 date "2016-12-28" @default.
- W2566573769 modified "2023-10-16" @default.
- W2566573769 title "Cathepsin B-degradable, NIR-responsive nanoparticulate platform for target-specific cancer therapy" @default.
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- W2566573769 doi "https://doi.org/10.1088/1361-6528/28/5/055101" @default.
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