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• W2566578375 abstract "Linear IgA bullous dermatosis (LABD) is a clinically and immunologically heterogeneous, subepidermal, autoimmune bullous disease (AIBD), for which the long-term evolution is poorly described.To investigate the clinical and immunological characteristics, follow-up and prognostic factors of adult idiopathic LABD.This retrospective study, conducted in our AIBD referral centre, included adults, diagnosed between 1995 and 2012, with idiopathic LABD, defined as pure or predominant IgA deposits by direct immunofluorescence. Clinical, histological and immunological findings were collected from charts. Standard histology was systematically reviewed, and indirect immunofluorescence (IIF) on salt-split skin (SSS) and immunoblots (IBs) on amniotic membrane extracts using anti-IgA secondary antibodies were performed, when biopsies and sera obtained at diagnosis were available. Prognostic factors for complete remission (CR) were identified using univariate and multivariate analyses.Of the 72 patients included (median age 54 years), 60% had mucous membrane (MM) involvement. IgA IIF on SSS was positive for 21 of 35 patients tested; 15 had epidermal and dermal labellings. Immunoelectron microscopy performed on the biopsies of 31 patients labelled lamina lucida (LL) (26%), lamina densa (23%), anchoring-fibril zone (AFz) (19%) and LL+AFz (23%). Of the 34 IgA IBs, 22 were positive, mostly for LAD-1/LABD97 (44%) and full-length BP180 (33%). The median follow-up was 39 months. Overall, 24 patients (36%) achieved sustained CR, 19 (29%) relapsed and 35% had chronic disease. CR was significantly associated with age > 70 years or no MM involvement. No prognostic immunological factor was identified.Patients with LABD who are < 70 years old and have MM involvement are at risk for chronic evolution." @default.
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• W2566578375 date "2017-05-15" @default.
• W2566578375 modified "2023-10-08" @default.
• W2566578375 title "Idiopathic linear IgA bullous dermatosis: prognostic factors based on a case series of 72 adults" @default.
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• W2566578375 doi "https://doi.org/10.1111/bjd.15244" @default.
• W2566578375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27995619" @default.
• W2566578375 hasPublicationYear "2017" @default.
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