FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2566581328> ?p ?o ?g. }

• W2566581328 abstract "We assessed the time courses of mitochondrial biogenesis factors and respiration in the right ventricle (RV), gastrocnemius (GAS), and left ventricle (LV) in a model of pulmonary-hypertensive rats. Monocrotaline (MT) rats and controls were studied 2 and 4 weeks after injection. Compensated and decompensated heart failure stages were defined according to obvious congestion signs. mRNA expression and protein level of peroxisome prolif- erator activated receptor gamma co-activator 1a (PGC-1a), citrate synthase (CS) mRNA and activity, and mitochon- drial respiration were investigated. In addition, mRNA expression of sirtuin1, nuclear respiratory factor 1, and mitochondrial transcription factor A were studied. As early as 2 weeks, the expression of the studied genes was decreased in the MT GAS. At 4 weeks, the MT GAS and MT RV showed decreased mRNA levels whatever the stage of disease, but PGC-1a protein and CS activity were signifi- cantly reduced only at the decompensated stage. The func- tional result was a significant fall in mitochondrial respiration at the decompensated stage in the RV and GAS. The mRNA expression and mitochondrial respiration were not signifi- cantly modified in the MT LV. MT rats demonstrated an early decrease in expression of genes involved in mitochondrial biogenesis in a skeletal muscle, whereas reduced protein expression, and the resulting mitochondrial respiratory dys- function appeared only in rats with overt heart failure, in the GAS and RV. Dissociations between mRNA and protein levels at the compensated stage deserve to be further studied." @default.
• W2566581328 created "2017-01-06" @default.
• W2566581328 creator A5051541462 @default.
• W2566581328 date "2013-01-01" @default.
• W2566581328 modified "2023-09-26" @default.
• W2566581328 title "Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension" @default.
• W2566581328 cites W1526273052 @default.
• W2566581328 cites W1911164619 @default.
• W2566581328 cites W1964307226 @default.
• W2566581328 cites W1968369233 @default.
• W2566581328 cites W1970032098 @default.
• W2566581328 cites W1972469636 @default.
• W2566581328 cites W1975443612 @default.
• W2566581328 cites W1982580503 @default.
• W2566581328 cites W1982802672 @default.
• W2566581328 cites W1991589560 @default.
• W2566581328 cites W1996495707 @default.
• W2566581328 cites W2001807631 @default.
• W2566581328 cites W2003661059 @default.
• W2566581328 cites W2012657513 @default.
• W2566581328 cites W2017311214 @default.
• W2566581328 cites W2026058722 @default.
• W2566581328 cites W2030702573 @default.
• W2566581328 cites W2063590495 @default.
• W2566581328 cites W2070481150 @default.
• W2566581328 cites W2074941472 @default.
• W2566581328 cites W2075066181 @default.
• W2566581328 cites W2075610661 @default.
• W2566581328 cites W2077633549 @default.
• W2566581328 cites W2083608115 @default.
• W2566581328 cites W2085804980 @default.
• W2566581328 cites W2087393295 @default.
• W2566581328 cites W2088086126 @default.
• W2566581328 cites W2091446398 @default.
• W2566581328 cites W2096007615 @default.
• W2566581328 cites W2096380667 @default.
• W2566581328 cites W2102672924 @default.
• W2566581328 cites W2102743559 @default.
• W2566581328 cites W2106549268 @default.
• W2566581328 cites W2107640353 @default.
• W2566581328 cites W2110155078 @default.
• W2566581328 cites W2118505232 @default.
• W2566581328 cites W2119545434 @default.
• W2566581328 cites W2120064241 @default.
• W2566581328 cites W2122910249 @default.
• W2566581328 cites W2124129878 @default.
• W2566581328 cites W2131197689 @default.
• W2566581328 cites W2136260739 @default.
• W2566581328 cites W2137134972 @default.
• W2566581328 cites W2144600435 @default.
• W2566581328 cites W2144867327 @default.
• W2566581328 cites W2149548143 @default.
• W2566581328 cites W2152205474 @default.
• W2566581328 cites W2154079280 @default.
• W2566581328 cites W2164016109 @default.
• W2566581328 cites W2165547205 @default.
• W2566581328 cites W2169580681 @default.
• W2566581328 cites W2169799265 @default.
• W2566581328 cites W2183341698 @default.
• W2566581328 cites W2403282630 @default.
• W2566581328 hasPublicationYear "2013" @default.
• W2566581328 type Work @default.
• W2566581328 sameAs 2566581328 @default.
• W2566581328 citedByCount "0" @default.
• W2566581328 crossrefType "journal-article" @default.
• W2566581328 hasAuthorship W2566581328A5051541462 @default.
• W2566581328 hasConcept C104317684 @default.
• W2566581328 hasConcept C105580179 @default.
• W2566581328 hasConcept C105702510 @default.
• W2566581328 hasConcept C111133373 @default.
• W2566581328 hasConcept C126322002 @default.
• W2566581328 hasConcept C134018914 @default.
• W2566581328 hasConcept C150194340 @default.
• W2566581328 hasConcept C181199279 @default.
• W2566581328 hasConcept C182215343 @default.
• W2566581328 hasConcept C2777229759 @default.
• W2566581328 hasConcept C2778198053 @default.
• W2566581328 hasConcept C2778921608 @default.
• W2566581328 hasConcept C2779959927 @default.
• W2566581328 hasConcept C2780930700 @default.
• W2566581328 hasConcept C28859421 @default.
• W2566581328 hasConcept C534529494 @default.
• W2566581328 hasConcept C55493867 @default.
• W2566581328 hasConcept C71924100 @default.
• W2566581328 hasConcept C86803240 @default.
• W2566581328 hasConcept C95444343 @default.
• W2566581328 hasConceptScore W2566581328C104317684 @default.
• W2566581328 hasConceptScore W2566581328C105580179 @default.
• W2566581328 hasConceptScore W2566581328C105702510 @default.
• W2566581328 hasConceptScore W2566581328C111133373 @default.
• W2566581328 hasConceptScore W2566581328C126322002 @default.
• W2566581328 hasConceptScore W2566581328C134018914 @default.
• W2566581328 hasConceptScore W2566581328C150194340 @default.
• W2566581328 hasConceptScore W2566581328C181199279 @default.
• W2566581328 hasConceptScore W2566581328C182215343 @default.
• W2566581328 hasConceptScore W2566581328C2777229759 @default.
• W2566581328 hasConceptScore W2566581328C2778198053 @default.
• W2566581328 hasConceptScore W2566581328C2778921608 @default.
• W2566581328 hasConceptScore W2566581328C2779959927 @default.
• W2566581328 hasConceptScore W2566581328C2780930700 @default.

• next