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• W2566584911 abstract "In most sexually reproducing organisms, crossover formation between homologous chromosomes is necessary for proper chromosome disjunction during meiosis I. During meiotic recombination, a subset of programmed DNA double-strand breaks (DSBs) are repaired as crossovers, with the remainder becoming noncrossovers [1]. Whether a repair intermediate is designated to become a crossover is a highly regulated decision that integrates several crossover patterning processes, both along chromosome arms (interference and the centromere effect) and between chromosomes (crossover assurance) [2]. Because the mechanisms that generate crossover patterning have remained elusive for over a century, it has been difficult to assess the relationship between crossover patterning and meiotic chromosome behavior. We show here that meiotic crossover patterning is lost in Drosophila melanogaster mutants that lack the Bloom syndrome helicase. In the absence of interference and the centromere effect, crossovers are distributed more uniformly along chromosomes. Crossovers even occur on the small chromosome 4, which normally never has meiotic crossovers [3]. Regulated distribution of crossovers between chromosome pairs is also lost, resulting in an elevated frequency of homologs that do not receive a crossover, which in turn leads to elevated nondisjunction." @default.
• W2566584911 created "2017-01-06" @default.
• W2566584911 creator A5020880841 @default.
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• W2566584911 date "2017-01-01" @default.
• W2566584911 modified "2023-10-15" @default.
• W2566584911 title "Bloom Syndrome Helicase Promotes Meiotic Crossover Patterning and Homolog Disjunction" @default.
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• W2566584911 doi "https://doi.org/10.1016/j.cub.2016.10.055" @default.
• W2566584911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5225052" @default.
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