FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2566699933> ?p ?o ?g. }

• W2566699933 endingPage "43" @default.
• W2566699933 startingPage "37" @default.
• W2566699933 abstract "Even if neoadjuvant chemotherapy (NACT) and oncoplastic techniques have increased the breast conserving surgery rate, mastectomy is still a standard for multifocal or extensive breast cancers (BC). In the prospect of increasing breast reconstruction, an alternative therapeutic protocol was developed combining NACT with neoadjuvant radiation therapy (NART), followed by mastectomy with immediate breast reconstruction (IBR). The oncological safety of this therapeutic plan still needs further exploration. We assessed pathological complete response (pCR) as a surrogate endpoint for disease free survival.Between 2010 and 2016, 103 patients undergoing mastectomy after NACT and NART were recruited. After CT and RT were administrated, a completion mastectomy with IBR by latissimus dorsi flap was achieved 6 to 8 weeks later. pCR was defined by the absence of residual invasive disease in both nodes and breast. Histologic response was analyzed for each immunohistochemical subset.pCR was obtained for 53.4% of the patients. This pCR rate was higher in hormonal receptor negative (HER2 and triple negative) patients when compared to luminal tumours (69.7% vs 45.7%, p=0.023).The pCR rate found in this study is higher than those published in studies analyzing NACT (12.5%-27.1%). This can be explained by the combination of anthracycline and taxane, the use of trastuzumab when HER2 was overexpressed but also by RT associated to NACT.Inverting the sequence protocol for BC, requiring both CT and RT, allows more IBR without diminishing pCR and should therefore be considered as an acceptable therapeutic option." @default.
• W2566699933 created "2017-01-06" @default.
• W2566699933 creator A5006642161 @default.
• W2566699933 creator A5013993492 @default.
• W2566699933 creator A5017940661 @default.
• W2566699933 creator A5020758672 @default.
• W2566699933 creator A5029712855 @default.
• W2566699933 creator A5048396097 @default.
• W2566699933 creator A5061803573 @default.
• W2566699933 creator A5064610455 @default.
• W2566699933 creator A5065530531 @default.
• W2566699933 creator A5072939671 @default.
• W2566699933 creator A5085946701 @default.
• W2566699933 creator A5091693659 @default.
• W2566699933 date "2017-04-01" @default.
• W2566699933 modified "2023-10-03" @default.
• W2566699933 title "Pathological complete response in invasive breast cancer treated by skin sparing mastectomy and immediate reconstruction following neoadjuvant chemotherapy and radiation therapy: Comparison between immunohistochemical subtypes" @default.
• W2566699933 cites W1955397179 @default.
• W2566699933 cites W1956784352 @default.
• W2566699933 cites W1979524230 @default.
• W2566699933 cites W1982319630 @default.
• W2566699933 cites W1996575748 @default.
• W2566699933 cites W2015351481 @default.
• W2566699933 cites W2017098623 @default.
• W2566699933 cites W2034948439 @default.
• W2566699933 cites W2036294483 @default.
• W2566699933 cites W2049871099 @default.
• W2566699933 cites W2052589067 @default.
• W2566699933 cites W2075894019 @default.
• W2566699933 cites W2080747590 @default.
• W2566699933 cites W2087179076 @default.
• W2566699933 cites W2095865154 @default.
• W2566699933 cites W2096145980 @default.
• W2566699933 cites W2116522870 @default.
• W2566699933 cites W2119549339 @default.
• W2566699933 cites W2129036785 @default.
• W2566699933 cites W2132893003 @default.
• W2566699933 cites W2139170567 @default.
• W2566699933 cites W2147415463 @default.
• W2566699933 cites W2151733225 @default.
• W2566699933 cites W2153158488 @default.
• W2566699933 cites W2153597941 @default.
• W2566699933 cites W2154142993 @default.
• W2566699933 cites W2158036908 @default.
• W2566699933 cites W2255006279 @default.
• W2566699933 cites W2293589105 @default.
• W2566699933 cites W2337600137 @default.
• W2566699933 cites W2337604319 @default.
• W2566699933 cites W967749364 @default.
• W2566699933 doi "https://doi.org/10.1016/j.breast.2016.12.014" @default.
• W2566699933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28033508" @default.
• W2566699933 hasPublicationYear "2017" @default.
• W2566699933 type Work @default.
• W2566699933 sameAs 2566699933 @default.
• W2566699933 citedByCount "19" @default.
• W2566699933 countsByYear W25666999332018 @default.
• W2566699933 countsByYear W25666999332019 @default.
• W2566699933 countsByYear W25666999332020 @default.
• W2566699933 countsByYear W25666999332021 @default.
• W2566699933 countsByYear W25666999332022 @default.
• W2566699933 countsByYear W25666999332023 @default.
• W2566699933 crossrefType "journal-article" @default.
• W2566699933 hasAuthorship W2566699933A5006642161 @default.
• W2566699933 hasAuthorship W2566699933A5013993492 @default.
• W2566699933 hasAuthorship W2566699933A5017940661 @default.
• W2566699933 hasAuthorship W2566699933A5020758672 @default.
• W2566699933 hasAuthorship W2566699933A5029712855 @default.
• W2566699933 hasAuthorship W2566699933A5048396097 @default.
• W2566699933 hasAuthorship W2566699933A5061803573 @default.
• W2566699933 hasAuthorship W2566699933A5064610455 @default.
• W2566699933 hasAuthorship W2566699933A5065530531 @default.
• W2566699933 hasAuthorship W2566699933A5072939671 @default.
• W2566699933 hasAuthorship W2566699933A5085946701 @default.
• W2566699933 hasAuthorship W2566699933A5091693659 @default.
• W2566699933 hasConcept C121608353 @default.
• W2566699933 hasConcept C126322002 @default.
• W2566699933 hasConcept C143998085 @default.
• W2566699933 hasConcept C207886595 @default.
• W2566699933 hasConcept C2776694085 @default.
• W2566699933 hasConcept C2777511904 @default.
• W2566699933 hasConcept C2777757722 @default.
• W2566699933 hasConcept C2778292576 @default.
• W2566699933 hasConcept C2779786085 @default.
• W2566699933 hasConcept C2781001896 @default.
• W2566699933 hasConcept C509974204 @default.
• W2566699933 hasConcept C530470458 @default.
• W2566699933 hasConcept C71924100 @default.
• W2566699933 hasConceptScore W2566699933C121608353 @default.
• W2566699933 hasConceptScore W2566699933C126322002 @default.
• W2566699933 hasConceptScore W2566699933C143998085 @default.
• W2566699933 hasConceptScore W2566699933C207886595 @default.
• W2566699933 hasConceptScore W2566699933C2776694085 @default.
• W2566699933 hasConceptScore W2566699933C2777511904 @default.
• W2566699933 hasConceptScore W2566699933C2777757722 @default.
• W2566699933 hasConceptScore W2566699933C2778292576 @default.
• W2566699933 hasConceptScore W2566699933C2779786085 @default.
• W2566699933 hasConceptScore W2566699933C2781001896 @default.
• W2566699933 hasConceptScore W2566699933C509974204 @default.

• next