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- W2566708515 startingPage "100610" @default.
- W2566708515 abstract "Plasmodium vivax populations are more resistant to malaria control strategies than Plasmodium falciparum , maintaining high genetic diversity and gene flow even at low transmission. To quantify the impact of declining transmission on P. vivax populations, we investigated population genetic structure over time during intensified control efforts and over a wide range of transmission intensities and spatial scales in the Southwest Pacific. Analysis of 887 P. vivax microsatellite haplotypes (Papua New Guinea, PNG = 443, Solomon Islands = 420, Vanuatu =24) revealed substantial population structure among countries and modestly declining diversity as transmission decreases over space and time. In the Solomon Islands, which has had sustained control efforts for 20 years, significant population structure was observed on different spatial scales down to the sub-village level. Up to 37% of alleles were partitioned between populations and significant multilocus linkage disequilibrium was observed indicating substantial inbreeding. High levels of haplotype relatedness around households and within a range of 300m are consistent with a focal and clustered infections suggesting that restricted local transmission occurs within the range of vector movement and that subsequent focal inbreeding may be a key factor contributing to the observed population structure. We conclude that unique transmission strategies, including relapse allows P. vivax populations to withstand pressure from control efforts for longer than P. falciparum . However sustained control efforts do eventually impact parasite population structure and with further control pressure, populations may eventually fragment into clustered foci that could be targeted for elimination." @default.
- W2566708515 created "2017-01-06" @default.
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- W2566708515 date "2016-12-01" @default.
- W2566708515 modified "2023-09-27" @default.
- W2566708515 title "Long-term sustained malaria control leads to inbreeding and fragmentation of Plasmodium vivax populations" @default.
- W2566708515 cites W103823305 @default.
- W2566708515 cites W111116732 @default.
- W2566708515 cites W135805148 @default.
- W2566708515 cites W1497104559 @default.
- W2566708515 cites W1499342446 @default.
- W2566708515 cites W1548928837 @default.
- W2566708515 cites W1595049023 @default.
- W2566708515 cites W1809424211 @default.
- W2566708515 cites W1832287255 @default.
- W2566708515 cites W1924088672 @default.
- W2566708515 cites W1961683076 @default.
- W2566708515 cites W1970939676 @default.
- W2566708515 cites W2001835403 @default.
- W2566708515 cites W2004444667 @default.
- W2566708515 cites W2006756465 @default.
- W2566708515 cites W2008789929 @default.
- W2566708515 cites W2015732607 @default.
- W2566708515 cites W2020142637 @default.
- W2566708515 cites W2025060142 @default.
- W2566708515 cites W2032012996 @default.
- W2566708515 cites W2035839217 @default.
- W2566708515 cites W2052410578 @default.
- W2566708515 cites W2054037475 @default.
- W2566708515 cites W2055008118 @default.
- W2566708515 cites W2055077703 @default.
- W2566708515 cites W2082781025 @default.
- W2566708515 cites W2088466434 @default.
- W2566708515 cites W2098126593 @default.
- W2566708515 cites W2098948919 @default.
- W2566708515 cites W2101904700 @default.
- W2566708515 cites W2102620261 @default.
- W2566708515 cites W2102670001 @default.
- W2566708515 cites W2103571367 @default.
- W2566708515 cites W2107421681 @default.
- W2566708515 cites W2107707420 @default.
- W2566708515 cites W2110186420 @default.
- W2566708515 cites W2111179758 @default.
- W2566708515 cites W2114469412 @default.
- W2566708515 cites W2114709340 @default.
- W2566708515 cites W2119800520 @default.
- W2566708515 cites W2121512231 @default.
- W2566708515 cites W2122683268 @default.
- W2566708515 cites W2122753628 @default.
- W2566708515 cites W2123386681 @default.
- W2566708515 cites W2125092464 @default.
- W2566708515 cites W2126455520 @default.
- W2566708515 cites W2131848771 @default.
- W2566708515 cites W2135178447 @default.
- W2566708515 cites W2137033565 @default.
- W2566708515 cites W2137862593 @default.
- W2566708515 cites W2138055306 @default.
- W2566708515 cites W2144207524 @default.
- W2566708515 cites W2147272002 @default.
- W2566708515 cites W2149299310 @default.
- W2566708515 cites W2150604056 @default.
- W2566708515 cites W2151409320 @default.
- W2566708515 cites W2156213211 @default.
- W2566708515 cites W2158694047 @default.
- W2566708515 cites W2159886246 @default.
- W2566708515 cites W2161339576 @default.
- W2566708515 cites W2161535656 @default.
- W2566708515 cites W2165020864 @default.
- W2566708515 cites W2168640201 @default.
- W2566708515 cites W2169399834 @default.
- W2566708515 cites W2170369422 @default.
- W2566708515 cites W2170556049 @default.
- W2566708515 cites W2170874271 @default.
- W2566708515 cites W2233681469 @default.
- W2566708515 cites W2235337769 @default.
- W2566708515 cites W2259457252 @default.
- W2566708515 cites W2296270886 @default.
- W2566708515 cites W2302162838 @default.
- W2566708515 cites W2334969423 @default.
- W2566708515 cites W2398640279 @default.
- W2566708515 cites W2440291058 @default.
- W2566708515 cites W2460939584 @default.
- W2566708515 cites W2462219738 @default.
- W2566708515 cites W2467177598 @default.