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- W2566739020 abstract "This chapter discusses the role of nanovesicles (NVs) in inflammation and coagulation, provide representative examples of their biological function and place them in clinical context. NVs are nanosized spherical vesicles defined by a lipid bilayer and continuously shed from the surfaces of both quiescent and stimulated cells. For years, the release of NVs by living cells has been considered a mechanism to dispose of unnecessary or damaged intracellular or membrane-bound molecules. Erythrocytes, leukocytes, platelets, and endothelial cells release NVs in blood, even under normal conditions. NVs convey intercellular signals either by the surface interactions or by the transfer of surface molecules and intravesicular content, such as mRNA, micro-RNA, proteins, lipids, and metabolites. The transfer of miRNA between malignant cells and cells of the immune system has widespread implications in cancer immunology. NVs released by dendritic cells might induce efficient T-cell immune response when loaded with a cognate antigen." @default.
- W2566739020 created "2017-01-06" @default.
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- W2566739020 date "2016-12-02" @default.
- W2566739020 modified "2023-09-26" @default.
- W2566739020 title "Human Nano-Vesicles in Physiology and Pathology" @default.
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- W2566739020 doi "https://doi.org/10.1002/9783527692057.ch6" @default.
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